CAJ | 학술논문

目的：探讨血清胱抑素C检测对老年慢性肾衰竭患者的临床意义。方法98例老年慢性肾衰竭患者为观察组，同期进行健康体检的36例老年人为对照组，两组均进行血清胱抑素C、肌酐和尿素氮检测，并比较分析。结果观察组血清胱抑素C、肌酐和尿素氮水平均显著高于对照组(P＜0.01)。观察组中Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期患者血清胱抑素C、肌酐和尿素氮水平比较，差异均有统计学意义(Ⅰ期＜Ⅱ期＜Ⅲ期＜Ⅳ期，P＜0.01)。在Ⅰ期患者中，胱抑素C检测的阳性率明显高于肌酐和尿素氮(P＜0.05)。结论血清胱抑素C可作为早期诊断老年慢性肾衰竭的敏感指标，并对判断病情严重程度有重要价值。
목적：탐토혈청광억소C검측대노년만성신쇠갈환자적림상의의。방법98례노년만성신쇠갈환자위관찰조，동기진행건강체검적36례노년인위대조조，량조균진행혈청광억소C、기항화뇨소담검측，병비교분석。결과관찰조혈청광억소C、기항화뇨소담수평균현저고우대조조(P＜0.01)。관찰조중Ⅰ기、Ⅱ기、Ⅲ기화Ⅳ기환자혈청광억소C、기항화뇨소담수평비교，차이균유통계학의의(Ⅰ기＜Ⅱ기＜Ⅲ기＜Ⅳ기，P＜0.01)。재Ⅰ기환자중，광억소C검측적양성솔명현고우기항화뇨소담(P＜0.05)。결론혈청광억소C가작위조기진단노년만성신쇠갈적민감지표，병대판단병정엄중정도유중요개치。
Objective To investigate the clinical signiifcance of serum cystatin C(Cys-C) testing in old patients with chronic renal failure(CRF).Methods98 patients with CRF were observation group. 36 healthy old people were served as the control. The levels of serum Cys-C, Scr, and BUN of the 2 groups were tested and compared.Results The levels of serum Cys-C, Scr, and BUN of the observation group were signiifcantly higher than those of the control(P<0.01). There were signiifcantly differences among periodⅠ, periodⅡ, periodⅢ, and periodⅣ patients in the observation group about the levels of Cys-C, Scr, and BUN(P<0.01). Positive rate of Cys-C testing in periodⅠ group was signiifcantly higher than those of Scr and BUN(P<0.05). ConclusionSerum Cys-C could be a sensitive indicator for early diagnosis in old patients with CRF, and it had an important value to evaluate the severity of the disease.