CAJ | 학술논문

目的：探讨不同严重程度分级的慢性阻塞性肺疾病急性加重期患者血浆血管性血友病因子水平及其意义。方法对86例不同严重程度分级的慢性阻塞性肺疾病急性加重期患者及24例健康者(对照组)进行血浆血管性血友病因子检测。结果各级慢性阻塞性肺疾病急性加重期患者血浆血管性血友病因子水平显著高于健康对照组(P＜0.05)，不同严重程度分级的慢性阻塞性肺疾病急性加重期患者之间的血浆血管性血友病因子水平均存在显著差异(P＜0.05)。结论血浆血管性血友病因子水平增高提示血管内皮细胞损伤及功能失调，慢性阻塞性肺疾病急性加重期患者存在血管内皮细胞损伤及功能失调，对治疗及预后存在不利影响。
목적：탐토불동엄중정도분급적만성조새성폐질병급성가중기환자혈장혈관성혈우병인자수평급기의의。방법대86례불동엄중정도분급적만성조새성폐질병급성가중기환자급24례건강자(대조조)진행혈장혈관성혈우병인자검측。결과각급만성조새성폐질병급성가중기환자혈장혈관성혈우병인자수평현저고우건강대조조(P＜0.05)，불동엄중정도분급적만성조새성폐질병급성가중기환자지간적혈장혈관성혈우병인자수평균존재현저차이(P＜0.05)。결론혈장혈관성혈우병인자수평증고제시혈관내피세포손상급공능실조，만성조새성폐질병급성가중기환자존재혈관내피세포손상급공능실조，대치료급예후존재불리영향。
Objective To investigate the levels and signiifcance of plasma von Willebrand factor(vWF) in patients with acute exacerbations of chronic obstructive pulmonary disease(AOCEPD).Methods The levels of plasma vWF of 24 healthy persons and 86 patients with AECOPD were detected.ResultsThe levels of plasma vWF in patients with AECOPD were signiifcantly higher(P<0.05) than that of healthy persons, and there was a significant difference(P<0.05) among different classification of severity in patients with AECOPD. Conclusion The increased levels of plasma vWF prompt endothelial cell injury and dysfunction, which would cause adverse effects on the treatment and prognosis of patients with AECOPD.