CAJ | 학술논문

目的：探讨三阴性乳腺癌（ TNBC）血管内皮生长因子（ VEGF）、P53的表达及临床意义。方法回顾性分析67例TNBC和125例NTNBC的临床病理特征，并应用免疫组织化学方法检测VEGF、P53在二者之间的表达差异。结果 VEGF在TNBC中的阳性表达率为70．1％，在NTNBC中的阳性表达率为32．8％，二者比较差异有统计学意义（ P ＜0．05）。 VEGF的表达与TNBC组的年龄、肿瘤大小、淋巴结转移、病理类型及病理学分级无关。 P53在TNBC中的阳性表达率为67．2％，在NTNBC中的阳性表达率为47．2％，二者比较差异有统计学意义（ P ＜0．05）。 P53的表达与TNBC组的年龄、肿瘤大小、淋巴结转移、病理类型及病理学分级无关（ P ＞0．05）。结论 TNBC有其独特的临床病理特征， VEGF、P53在TNBC组织中高表达，提示其恶性程度高，侵袭性强，预后差，VEGF、P53可以做为评估TNBC预后的重要参考因素。
목적：탐토삼음성유선암（ TNBC）혈관내피생장인자（ VEGF）、P53적표체급림상의의。방법회고성분석67례TNBC화125례NTNBC적림상병리특정，병응용면역조직화학방법검측VEGF、P53재이자지간적표체차이。결과 VEGF재TNBC중적양성표체솔위70．1％，재NTNBC중적양성표체솔위32．8％，이자비교차이유통계학의의（ P ＜0．05）。 VEGF적표체여TNBC조적년령、종류대소、림파결전이、병리류형급병이학분급무관。 P53재TNBC중적양성표체솔위67．2％，재NTNBC중적양성표체솔위47．2％，이자비교차이유통계학의의（ P ＜0．05）。 P53적표체여TNBC조적년령、종류대소、림파결전이、병리류형급병이학분급무관（ P ＞0．05）。결론 TNBC유기독특적림상병리특정， VEGF、P53재TNBC조직중고표체，제시기악성정도고，침습성강，예후차，VEGF、P53가이주위평고TNBC예후적중요삼고인소。
Objective To investigate the expression and clinical significance of vascular endothelial growth factor (VEGF),P53 in patients with triple negative breast cancer (TNBC).Methods The clinicopathological characteristics in 67 cases of human TNBC and 125 cases of non TNBC ( NTNBC ) were retrospectively analyzed , and the expression levels of VEGF,P53 in the two groups were detected by immunohistochemistry .Results The positive expression rate of VEGF was 70. 1%in TNBC group,which was 32.8%in NTNBC group,there was a significant difference between two groups ( P <0.05). The expression of VEGF was not correlated to patient 's age, tumor size, lymph node metastasis, pathological types and histological classification in TNBC group.The positive expression rate of P53 in TNBC group was 67.2% in TNBC,however, which was 47.2%in NTNBC group,there was a significant difference between two groups ( P <0.05).The expression of P53 was not related with patien's age,tumor size,lymph node metastasis ,pathological types and pathological grading in TNBC group ( P >0.05).Conclusion The TNBC has unique clinicopathological characteristics .The overexpression of VEGF,P53 in TNBC tissues is closely correlated to high malignant degree ,tremendous invasion and poor prognosis ,therefore VEGF and P53 can be used as important reference indexes for evaluating prognosis of patients with TNBC .