吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2014年
25期
5598-5600
,共3页
百草枯中毒%免疫抑制剂%Meta分析%预后
百草枯中毒%免疫抑製劑%Meta分析%預後
백초고중독%면역억제제%Meta분석%예후
Paraquat poisoning%Immunosuppressive therapy%Meta-analysis%Prognosis
目的：探讨免疫抑制剂对百草枯的治疗效果。方法：检索国内外公开发表免疫抑制剂治疗百草枯中毒的中英文文献，通过Stata软件进行Meta分析。结果：根据纳人和剔除标准筛选出10篇文献，其中8篇为历史对照的观察性研究，2篇为随机对照试验研究。Meta分析表明免疫抑制剂对百草枯中毒的预后有显著改善。历史对照的观察性研究RR=0.54，95% CI：0.44~0.66，RCT研究RR=0.76，95% CI：0.62~0.94。结论：免疫抑制剂治疗对百草枯中毒的生存率改善明显。但目前的文献存在异质性，证据尚不够充分。需要进行更多的RCT试验以进一步明确。
目的：探討免疫抑製劑對百草枯的治療效果。方法：檢索國內外公開髮錶免疫抑製劑治療百草枯中毒的中英文文獻，通過Stata軟件進行Meta分析。結果：根據納人和剔除標準篩選齣10篇文獻，其中8篇為歷史對照的觀察性研究，2篇為隨機對照試驗研究。Meta分析錶明免疫抑製劑對百草枯中毒的預後有顯著改善。歷史對照的觀察性研究RR=0.54，95% CI：0.44~0.66，RCT研究RR=0.76，95% CI：0.62~0.94。結論：免疫抑製劑治療對百草枯中毒的生存率改善明顯。但目前的文獻存在異質性，證據尚不夠充分。需要進行更多的RCT試驗以進一步明確。
목적：탐토면역억제제대백초고적치료효과。방법：검색국내외공개발표면역억제제치료백초고중독적중영문문헌，통과Stata연건진행Meta분석。결과：근거납인화척제표준사선출10편문헌，기중8편위역사대조적관찰성연구，2편위수궤대조시험연구。Meta분석표명면역억제제대백초고중독적예후유현저개선。역사대조적관찰성연구RR=0.54，95% CI：0.44~0.66，RCT연구RR=0.76，95% CI：0.62~0.94。결론：면역억제제치료대백초고중독적생존솔개선명현。단목전적문헌존재이질성，증거상불구충분。수요진행경다적RCT시험이진일보명학。
Objective To evaluate the effect of immunosuppressive therapy for paraquat poisoning. Method Relevant published articles concemed with immunosuppressive therapy for paraquat poisoning both in Chinese and in English were searched,and Meta-analysis was carried out with Stata software. Results Eight non-randomized comparative studies and two randomized controlled trials were enrolled for Meta-analysis according to the inclusion and exclusion criteria. The results indicated the relative risk of immunosuppressive therapy in im-proving mortality of paraquat poisoning were 0. 54(95% CI=0. 44~0. 66)and 0. 76(95% CI=0. 62~0. 94)for non-randomised stud-ies and randomized controlled studies,respectively. Conclusion This anaIysis Suggests that immunosuppressive therapy reduce mortality in paraquat poisoning compared with conventional medical therapy. However,due to significant heterogeneity,a large randomized controlled trial is required to affirm the role of immunosuppression in paraquat poisoning.
