中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
24期
141-142
,共2页
胡威%刘光普%李劲松%张敬泉
鬍威%劉光普%李勁鬆%張敬泉
호위%류광보%리경송%장경천
星形细胞瘤%星形细胞上调基因-1%免疫组化
星形細胞瘤%星形細胞上調基因-1%免疫組化
성형세포류%성형세포상조기인-1%면역조화
Astrocytoma%Astrocyte elevated gene-1%Immunochemistry
目的：探讨星形细胞上调基因-1(AEG-1)在星形细胞瘤的表达及与其临床病理特征的相关性。方法：应用免疫组织化学检测星形细胞瘤和正常脑组织AEG-1的表达情况，并分析其与星形细胞瘤临床病理特征的关系。结果：AEG-1全部着色在胞浆。AEG-1在80例星形细胞瘤组织中的阳性表达率为87.5%，高于20例正常脑组织的5.0%(P<0.05)。肿瘤较小、低级别、可以完全切除的患者，AEG-1的阳性表达水平低(P<0.05)。结论：AEG-1在星形细胞瘤中呈过表达，参与星形细胞瘤的发生、发展。
目的：探討星形細胞上調基因-1(AEG-1)在星形細胞瘤的錶達及與其臨床病理特徵的相關性。方法：應用免疫組織化學檢測星形細胞瘤和正常腦組織AEG-1的錶達情況，併分析其與星形細胞瘤臨床病理特徵的關繫。結果：AEG-1全部著色在胞漿。AEG-1在80例星形細胞瘤組織中的暘性錶達率為87.5%，高于20例正常腦組織的5.0%(P<0.05)。腫瘤較小、低級彆、可以完全切除的患者，AEG-1的暘性錶達水平低(P<0.05)。結論：AEG-1在星形細胞瘤中呈過錶達，參與星形細胞瘤的髮生、髮展。
목적：탐토성형세포상조기인-1(AEG-1)재성형세포류적표체급여기림상병리특정적상관성。방법：응용면역조직화학검측성형세포류화정상뇌조직AEG-1적표체정황，병분석기여성형세포류림상병리특정적관계。결과：AEG-1전부착색재포장。AEG-1재80례성형세포류조직중적양성표체솔위87.5%，고우20례정상뇌조직적5.0%(P<0.05)。종류교소、저급별、가이완전절제적환자，AEG-1적양성표체수평저(P<0.05)。결론：AEG-1재성형세포류중정과표체，삼여성형세포류적발생、발전。
Objective:To investigate the expression of AEG-1 in astrocytomas and the relationship between AEG-1 and the clinicopathologic status. Method:Immunohistochemical method was performed to detect the expression of AEG-1 in 60 astrocytomas tissues and 20 normal brain tissues.To evaluate the relationship between AEG-1 and clinicopathologic status in astrocytomas.Result:AEG-1 was evident in cytoplasmic of astrocytomas.Of 80 astrocytomas tissues, 70(87.5%) were stained positive for AEG-1,higher than that in normal brain tissues(1/20,2.0%)(P<0.05).Smaller tumor,earlier stage and total Resection were associated with overexpressed AEG-1(P<0.05).Conclusion:The overexpression of AEG-1 is high in astrocytomas,AEG-1 is associated with the occurrence of astrocytomas.
