CAJ | 학술논문

目的：红花注射液对急性肺损伤小儿患者血清TNF-α及IL-8水平的影响。方法：选取近期我院收治的急性肺损伤小儿患者60例，分为损伤组和红花注射液治疗组，损伤组常规应用药物治疗，治疗组在常规治疗的基础上，加入红花注射液治疗。选取同期体检的健康儿童30例，作为正常对照组。以ELISA法检测各组血清TNF-α及IL-8水平。结果：与正常对照组相比，急性肺损伤小儿患者组血清TNF-α及IL-8水平明显升高（P<0.05），与损伤组相比，红花注射液治疗组患者TNF-α及IL-8水平明显降低（P<0.05）。结论：红花注射液通过抑制急性肺损伤小儿患者血清TNF-α及IL-8水平来减轻肺损伤。
목적：홍화주사액대급성폐손상소인환자혈청TNF-α급IL-8수평적영향。방법：선취근기아원수치적급성폐손상소인환자60례，분위손상조화홍화주사액치료조，손상조상규응용약물치료，치료조재상규치료적기출상，가입홍화주사액치료。선취동기체검적건강인동30례，작위정상대조조。이ELISA법검측각조혈청TNF-α급IL-8수평。결과：여정상대조조상비，급성폐손상소인환자조혈청TNF-α급IL-8수평명현승고（P<0.05），여손상조상비，홍화주사액치료조환자TNF-α급IL-8수평명현강저（P<0.05）。결론：홍화주사액통과억제급성폐손상소인환자혈청TNF-α급IL-8수평래감경폐손상。
Objective:To study the change of the serum TNF-α, IL-8 with the Honghua injection in children with acute lung injury. Methods:Children were randomly divided into three groups, normal control group, the acute lung injury group and the Honghua treatment group, the serum TNF-α, IL-8 were observed by ELISA. Results:The level of the serum TNF-α, IL-8 in the Honghua treatment group were significantly higher than that in the control group (P<0.05), compared with the acute lung injury group, the level of the serum TNF-α, IL-8 in the Honghua treatment group were significantly decreased (P<0.05). Conclusion: The Honghua injection could improve the injury of lungs through inhibit levels of the serum TNF-αand IL-8 in children with acute lung injury.