中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
24期
41-42,43
,共3页
视黄醇结合蛋白%胱抑素C%β2微球蛋白%2型糖尿病%早期肾损害
視黃醇結閤蛋白%胱抑素C%β2微毬蛋白%2型糖尿病%早期腎損害
시황순결합단백%광억소C%β2미구단백%2형당뇨병%조기신손해
Retinol binding protein%Cystatin C%β2 microglobulin%Type 2 diabetes mellitus%Early renal damage
目的：探讨视黄醇结合蛋白(RBP)、胱抑素C(Cys C)及β2微球蛋白(β2-MG)联检对2型糖尿病(T2DM)早期肾损害的诊断价值。方法：将选取的125例T2DM患者根据尿白蛋白排泄率分成正常蛋白尿组(62例)、微量蛋白尿组(63例)，另选健康体检人员45例做对照组，所有受检者血清RBP采用免疫透射比浊法检测，Cys C、β2-MG采用颗粒增强免疫透射比浊法检测。结果：微量蛋白尿组血清RBP、Cys C、β2-MG、Urea及Crea含量及阳性率较另外两组高(P<0.05)；正常蛋白尿组RBP、Cys C及β2-MG含量及阳性率较对照组高(P<0.05)；两试验组RBP、Cys C、β2-MG阳性率较Urea或Crea高(P<0.05)；两试验组RBP与Cys C联检的阳性率较单项指标高，RBP、Cys C与β2-MG三项联检时阳性率较RBP与Cys C两项联检高(P<0.05)。结论：RBP、Cys C及β2-MG可作为T2DM早期肾损伤诊断的有价值的指标，联合检测意义更大。
目的：探討視黃醇結閤蛋白(RBP)、胱抑素C(Cys C)及β2微毬蛋白(β2-MG)聯檢對2型糖尿病(T2DM)早期腎損害的診斷價值。方法：將選取的125例T2DM患者根據尿白蛋白排洩率分成正常蛋白尿組(62例)、微量蛋白尿組(63例)，另選健康體檢人員45例做對照組，所有受檢者血清RBP採用免疫透射比濁法檢測，Cys C、β2-MG採用顆粒增彊免疫透射比濁法檢測。結果：微量蛋白尿組血清RBP、Cys C、β2-MG、Urea及Crea含量及暘性率較另外兩組高(P<0.05)；正常蛋白尿組RBP、Cys C及β2-MG含量及暘性率較對照組高(P<0.05)；兩試驗組RBP、Cys C、β2-MG暘性率較Urea或Crea高(P<0.05)；兩試驗組RBP與Cys C聯檢的暘性率較單項指標高，RBP、Cys C與β2-MG三項聯檢時暘性率較RBP與Cys C兩項聯檢高(P<0.05)。結論：RBP、Cys C及β2-MG可作為T2DM早期腎損傷診斷的有價值的指標，聯閤檢測意義更大。
목적：탐토시황순결합단백(RBP)、광억소C(Cys C)급β2미구단백(β2-MG)련검대2형당뇨병(T2DM)조기신손해적진단개치。방법：장선취적125례T2DM환자근거뇨백단백배설솔분성정상단백뇨조(62례)、미량단백뇨조(63례)，령선건강체검인원45례주대조조，소유수검자혈청RBP채용면역투사비탁법검측，Cys C、β2-MG채용과립증강면역투사비탁법검측。결과：미량단백뇨조혈청RBP、Cys C、β2-MG、Urea급Crea함량급양성솔교령외량조고(P<0.05)；정상단백뇨조RBP、Cys C급β2-MG함량급양성솔교대조조고(P<0.05)；량시험조RBP、Cys C、β2-MG양성솔교Urea혹Crea고(P<0.05)；량시험조RBP여Cys C련검적양성솔교단항지표고，RBP、Cys C여β2-MG삼항련검시양성솔교RBP여Cys C량항련검고(P<0.05)。결론：RBP、Cys C급β2-MG가작위T2DM조기신손상진단적유개치적지표，연합검측의의경대。
Objective:To study the diagnostic value of srum retinol binding protein(RBP),cystatin C(Cys C) andβ2 microglobulin(β2-MG) in early renal damage.Method:125 case of T2DM were selected.The urinary albumin excretion rate(UAER) of 62 Patients with T2DM was less than 20μg/min was normal albuminuria group,the UAER of 63 patients with T2DM was situated between 20μg/min and 200μg/min was microalbuminuria group.45 cases of healthy people was control group.RBP was tested by the immune turbidimetric method,Cys C andβ2-MG were test by particle enhanced immuno turbidimetric assay. Result:The content and the positive rate of RBP,Cys C,β2-MG、ureaand creatinine in microalbuminuria group were higher than other two groups(P<0.05).The Content and the positive rate of RBP,Cys C,β2-MG in normal albuminuria group were higher than control group(P<0.05).The positive rate of RBP and Cys C was higher than RBP or Cys C(P<0.05).The positive rate of RBP,Cys C orβ2-MG in the two experimental group were higher than Urea or Crea(P<0.05).The positive rate of RBP,Cys C andβ2-MG in the two experimental group were higher than RBP and Cys C(P<0.05).Conclusion:RBP,Cys C andβ2-MG can be used as marker in diagnosis type 2 diabetes mellitus early renal damage,the clinical value of combined detection is greater.
