中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2014年
24期
141-142,144
,共3页
甲状腺自身抗体%TPOAb%TgAb%TRAb%抗原表位
甲狀腺自身抗體%TPOAb%TgAb%TRAb%抗原錶位
갑상선자신항체%TPOAb%TgAb%TRAb%항원표위
Thyroid autoantibodies%TPOAb%TgAb%TRAb%Epitope
甲状腺自身抗体主要包括抗甲状腺球蛋白、抗甲状腺过氧化物酶及抗促甲状腺素受体的自身抗体，长期以来被当作自身免疫性甲状腺病的血清学标志。近年来的研究显示甲状腺自身抗体抗原表位可影响其功能。对于甲状腺自身抗体抗原表位及功能的研究，有助于获得其功能性分子，用于自身抗体的检测，未来更有望用于AITD、甲状腺癌等疾病的诊断、治疗，以及对疾病预后的预测。
甲狀腺自身抗體主要包括抗甲狀腺毬蛋白、抗甲狀腺過氧化物酶及抗促甲狀腺素受體的自身抗體，長期以來被噹作自身免疫性甲狀腺病的血清學標誌。近年來的研究顯示甲狀腺自身抗體抗原錶位可影響其功能。對于甲狀腺自身抗體抗原錶位及功能的研究，有助于穫得其功能性分子，用于自身抗體的檢測，未來更有望用于AITD、甲狀腺癌等疾病的診斷、治療，以及對疾病預後的預測。
갑상선자신항체주요포괄항갑상선구단백、항갑상선과양화물매급항촉갑상선소수체적자신항체，장기이래피당작자신면역성갑상선병적혈청학표지。근년래적연구현시갑상선자신항체항원표위가영향기공능。대우갑상선자신항체항원표위급공능적연구，유조우획득기공능성분자，용우자신항체적검측，미래경유망용우AITD、갑상선암등질병적진단、치료，이급대질병예후적예측。
Thyroid autoantibodies mainly including anti-thyroglobulin, anti-thyroid peroxidase, and Anti-thyroid stimulating hormone (TSH) receptor antibodies, have been taken as serological markers of autoimmune thyroid disease for a long time. Studies in recent years have shown that epitopes of thyroid autoantibody can affect its function. Research on these epitopes and their functions can help obtain functional molecules, which can be used to detect the autoantibodies. In the future they are even expected to be used for the diagnosis and treatment of AITD, thyroid cancer and other diseases, as well as the prediction of the prognosis.
