CAJ | 학술논문

目的：通过对雷公藤制剂所致血液系统毒性反应病例进行回顾性分析，从临床护理角度提高认识及应对。方法：检索中国生物医学文献数据库、中国期刊全文数据库及中文科技期刊数据库，收集雷公藤制剂引起血液系统毒性反应的病例，对毒性反应的发生特点进行归纳总结。结果：共检索到文献19篇，病例25例，其毒性反应主要表现为：全身不适，腹痛，腹泻，伴发热，重度贫血、鼻出血、皮肤瘀斑等，严重者可致急性再生障碍性贫血、粒细胞缺乏症、骨髓抑制、类白血病反应等。结论：雷公藤制剂具有血液毒性，在用药过程中应严格掌握其适应证和禁忌证，临床护理工作非常重要，关注配伍减毒、控制给药时间以及观察药物毒性反应等。
목적：통과대뢰공등제제소치혈액계통독성반응병례진행회고성분석，종림상호리각도제고인식급응대。방법：검색중국생물의학문헌수거고、중국기간전문수거고급중문과기기간수거고，수집뢰공등제제인기혈액계통독성반응적병례，대독성반응적발생특점진행귀납총결。결과：공검색도문헌19편，병례25례，기독성반응주요표현위：전신불괄，복통，복사，반발열，중도빈혈、비출혈、피부어반등，엄중자가치급성재생장애성빈혈、립세포결핍증、골수억제、류백혈병반응등。결론：뢰공등제제구유혈액독성，재용약과정중응엄격장악기괄응증화금기증，림상호리공작비상중요，관주배오감독、공제급약시간이급관찰약물독성반응등。
Objective: To retrospectively analyze the blood system toxicity caused by tripterygium wilfordii agents reported in literatures of adverse reaction cases in order to put forward advice and countermeasures from the perspective of nursing. Methods: To retrieve the Chinese biomedical literature database, China journal full-text database and Chinese science and technology periodical database, collect cases of toxicity of tripterygium wilfordii agents leading to blood system and summarize the characteristic of its adverse reactions. Results: 19 references, 25 cases were collected with main manifestations of the whole body discomfort, abdominal pain, diarrhea, associated with fever, severe anemia, nose bleeding, skin ecchymosis, severe cases with acute aplastic anemia and pure red aplastic anemia and agranulocytosis, bone marrow suppression, type of leukemia, etc. Conclusion:Due to Tripterygium wilfordii agents with blood system toxicity, nursing is very important in the process of drug, the nursing should strictly follow the indications and contraindications, reasonable control of delivery time and focus on compatibility attenuated and taboos.