CAJ | 학술논문

目的：研究探讨AIDS患者的治疗对其凝血功能的影响。方法选取我院收治的AIDS患者32例作为研究对象，将其作为观察组，同时选择自愿参与实验研究的健康受试者40例作为对照组，对两组受试者的凝血功能进行检测，对比较其血液中血小板、D-二聚体、血浆纤维蛋白原的水平以及血浆凝血酶原时间、活化部分凝血酶时间等相关指标，分析高效抗逆转录病毒联合治疗对AIDS患者凝血功能的影响情况。结果凝血各项相关检查指标的比较显示，观察组AIDS患者的D-二聚体、血浆纤维蛋白原的水平以及血浆凝血酶原时间、活化部分凝血酶时间等显著高于健康对照组的受试者，而血小板参数显著低于对照组受试者，各项凝血检查指标之间的比较均差异显著，且P＜0.05，具有统计学意义。结论高效抗逆转录病毒联合治疗艾滋病会导致患者血液处于严重高凝状态，因而在临床要考虑联合抗凝血药物进行治疗。
목적：연구탐토AIDS환자적치료대기응혈공능적영향。방법선취아원수치적AIDS환자32례작위연구대상，장기작위관찰조，동시선택자원삼여실험연구적건강수시자40례작위대조조，대량조수시자적응혈공능진행검측，대비교기혈액중혈소판、D-이취체、혈장섬유단백원적수평이급혈장응혈매원시간、활화부분응혈매시간등상관지표，분석고효항역전록병독연합치료대AIDS환자응혈공능적영향정황。결과응혈각항상관검사지표적비교현시，관찰조AIDS환자적D-이취체、혈장섬유단백원적수평이급혈장응혈매원시간、활화부분응혈매시간등현저고우건강대조조적수시자，이혈소판삼수현저저우대조조수시자，각항응혈검사지표지간적비교균차이현저，차P＜0.05，구유통계학의의。결론고효항역전록병독연합치료애자병회도치환자혈액처우엄중고응상태，인이재림상요고필연합항응혈약물진행치료。
Objective Study investigated the effects of AIDS patients treated its clotting function. Methods Select the AIDS patients in our hospital 32 cases as a research object, as in the observation group, while voluntarily participating in the experiment studied 40 cases of healthy subjects as the control group, two groups of subjects coagulation testing, comparative their blood platelets, D-dimer, ifbrinogen levels and prothrombin time, activated partial thromboplastin time, and other related indicators, the analysis of highly active antiretroviral combination therapy for AIDS patients affect coagulation situation. Results Compare coagulation indicators show the relevant checks, signiifcantly higher than the healthy control group subjects AIDS patients in the observation group D-dimer, ifbrinogen levels and prothrombin time, activated partial thromboplastin time, and platelet parameters were signiifcantly lower than control subjects, comparing various indicators of coagulation checks were signiifcant differences between, andP <0.05, statistically signiifcant. Conclusion Highly active antiretroviral combination therapy in patients with AIDS can cause severe blood is hypercoagulable state, and therefore to be considered in the clinical treatment combined with anti-clotting drugs.