CAJ | 학술논문

目的：探讨依达拉奉联合尼卡地平对肝癌患者肝脏缺血再灌注损伤的保护作用的临床研究。方法80例患者随机分为四组，A组：肝阻断前20min恒速静脉输入生理盐水250mL。B组：阻断前20min输入尼卡地平。C组：阻断前20min恒速静脉输入依达拉奉。D组：阻断前20min静脉输入尼卡地平和依达拉奉。于手术前（T0）和肝切除后30min（T1）、1h（T2）、术后1d（T3）和2d（T4）取静脉血行丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）测定，取切下肝脏组织相对正常的肝组织测定丙二醛（MDA）及超氧化物歧化酶（SOD）的含量。结果肝细胞匀浆中的MDA水平在C、D组比对照组A组比较低，差异有显著性（P＜0.05）。SOD含量C、D组比对照组A组比较高，差异有显著性（P＜0.05）。在肝切除后30min（T1）、1h（T2）、术后1d（T3）和2d（T4）各时间点血清中ALT、AST含量B、C组与对照组比较差异有统计学意义（P＜0.05），D组与对照组比较差异有统计学意义（P＜0.01）。结论依达拉奉联合尼卡地平使用对肝脏缺血再灌注损伤有一定保护作用，且具有协同效果。
목적：탐토의체랍봉연합니잡지평대간암환자간장결혈재관주손상적보호작용적림상연구。방법80례환자수궤분위사조，A조：간조단전20min항속정맥수입생리염수250mL。B조：조단전20min수입니잡지평。C조：조단전20min항속정맥수입의체랍봉。D조：조단전20min정맥수입니잡지평화의체랍봉。우수술전（T0）화간절제후30min（T1）、1h（T2）、술후1d（T3）화2d（T4）취정맥혈행병안산전안매（ALT）화천동안산전안매（AST）측정，취절하간장조직상대정상적간조직측정병이철（MDA）급초양화물기화매（SOD）적함량。결과간세포균장중적MDA수평재C、D조비대조조A조비교저，차이유현저성（P＜0.05）。SOD함량C、D조비대조조A조비교고，차이유현저성（P＜0.05）。재간절제후30min（T1）、1h（T2）、술후1d（T3）화2d（T4）각시간점혈청중ALT、AST함량B、C조여대조조비교차이유통계학의의（P＜0.05），D조여대조조비교차이유통계학의의（P＜0.01）。결론의체랍봉연합니잡지평사용대간장결혈재관주손상유일정보호작용，차구유협동효과。
Objective To investigate the protective effects of nicardipine combined with edaravone on hepatic ischemia-reperfusion injury. Methods Selected 80 patients, and they were randomly divided into four groups, pretreatment with saline (A); pretreatment with nicardipine (B); pretreatment with edaravone (C); pretreatment with nicardipine combined with edaravone (D). The concentrations of alanine transaminase (ALT), aspartate aminotransferase (AST) in serum were measured. Hepatic cell homogenate levels of MDA, SOD were measured. Results Hepatic cell homogenate levels of MDA were lower in C, D than that in group A(P<0.05), and SOD were higher (P<0.05). In the T1, T2, T3 and T4, the plasma levers of ALT, AST were lower in group B, C than that in group A (P<0.05), those were remarkably lower group D than that in group A (P<0.01). Conclusion The nicardipine combined with edaravone in the treatment for hepatic ischemia-reperfusion injury has protective effects, and has obvious synergies.