CAJ | 학술논문

目的：观察顺式阿曲库铵联合维库溴铵用药后ED50和ED95的变化。方法将75例择期手术患者(ASAⅠ~Ⅱ级)随机分为3组：顺式阿曲库铵组、维库溴铵组和顺式阿曲库铵+维库溴铵组，每组各25例。麻醉诱导后，以单次给药法观察起效时间和T1达到最大抑制的时间，描绘3组患者的量-效曲线，求得各自的ED50和ED95值，并运用等效图法和代数法对两药相互作用进行分析。结果单用顺式阿曲库铵组、维库溴铵组ED50值分别为32.35、28.78μg/kg，ED95值分别为52.67、51.20μg/kg。联合用药时ED50值为16.81、12.17μg/kg，ED95值为23.49、22.16μg/kg，与单独用药相比，差异均有统计学意义。联合用药时ED50和ED95的合用代数值分别为0.942、0.879。结论联合使用顺式阿曲库铵和维库溴铵具有协同作用，且量-效曲线产生左移。
목적：관찰순식아곡고안연합유고추안용약후ED50화ED95적변화。방법장75례택기수술환자(ASAⅠ~Ⅱ급)수궤분위3조：순식아곡고안조、유고추안조화순식아곡고안+유고추안조，매조각25례。마취유도후，이단차급약법관찰기효시간화T1체도최대억제적시간，묘회3조환자적량-효곡선，구득각자적ED50화ED95치，병운용등효도법화대수법대량약상호작용진행분석。결과단용순식아곡고안조、유고추안조ED50치분별위32.35、28.78μg/kg，ED95치분별위52.67、51.20μg/kg。연합용약시ED50치위16.81、12.17μg/kg，ED95치위23.49、22.16μg/kg，여단독용약상비，차이균유통계학의의。연합용약시ED50화ED95적합용대수치분별위0.942、0.879。결론연합사용순식아곡고안화유고추안구유협동작용，차량-효곡선산생좌이。
Objective To observe the change of ED50 and ED95 for the treatment with cisatracurium and vecuronium. Methods 75 cases of patients undergoing elective surgery (ASA Ⅰ to II level) were ramdomly divided into three groups:cisatracurium group,vecuronium group and cisatracurium+vecuronium group,each group of 25 cases.The onset time and T1 maximum inhibition time were determined by the single-injection doseresponse technique after anesthesia induction.Their respective ED50 of ED95 values were caculated by the depicted dose-response curve among the three groups of patients.The two medicine interaction analysis was caculated by the equivalent diagram method and algebraic method. Results ED50 was 32.35,28.78 μg/kg and ED95 was 52.67,51.20 μg/kg when patients were given single dose of atracurium or vecuronium.ED50 was 16.81,12.17 μg/kg and ED95 was 23.49,22.16 μg/kg when it combined the both two groups.Compared with other group,the differences in cisatracurium+vecuronium group were statistically significant.The combinational value of ED50 and ED95 was 0.942 and 0.879,respectively. Conclusion The combination of cisatracurium and vecuronium produces synergy effect and shifts the dose-response curve to the left.