CAJ | 학술논문

目的：分析不同剂量瑞格列奈对2型糖尿病患者治疗效果的影响。方法资料随机选自2013年2月~2014年2月在本院确诊为2型糖尿病且接受瑞格列奈治疗患者96例，依据每日瑞格列奈服用剂量随机分成3组，每组32例，对照组剂量为1.0 mg/d，研究A组为1.5 mg/d，研究B组为2.0 mg/d，比较3组患者的血糖指标、临床疗效与不良反应发生情况。结果3组患者治疗后的FINS、HOMA-β与HOMA-IR水平、血糖达标时间比较，差异无统计学意义(P>0.05)；研究B组的低血糖发生率(21.88%)高于对照组的0(P<0.05)；对照组治疗后的FBG与2 h PG高于研究A、B组(P<0.05)。结论2型糖尿病患者瑞格列奈每日服用最佳剂量为1.0 mg，能够有效控制血糖且降低低血糖发生风险。
목적：분석불동제량서격렬내대2형당뇨병환자치료효과적영향。방법자료수궤선자2013년2월~2014년2월재본원학진위2형당뇨병차접수서격렬내치료환자96례，의거매일서격렬내복용제량수궤분성3조，매조32례，대조조제량위1.0 mg/d，연구A조위1.5 mg/d，연구B조위2.0 mg/d，비교3조환자적혈당지표、림상료효여불량반응발생정황。결과3조환자치료후적FINS、HOMA-β여HOMA-IR수평、혈당체표시간비교，차이무통계학의의(P>0.05)；연구B조적저혈당발생솔(21.88%)고우대조조적0(P<0.05)；대조조치료후적FBG여2 h PG고우연구A、B조(P<0.05)。결론2형당뇨병환자서격렬내매일복용최가제량위1.0 mg，능구유효공제혈당차강저저혈당발생풍험。
Objective To analyze the influence of different dosage of repaglinide on treatment effect of type 2 diabetes mellitus. Methods 96 cases with type 2 diabetes mellitus treated with repaglinide in our hospital from February 2013 to February 2014 were selected and divided into the three groups according to the dosage of repaglinide,each group for 32 cases.The dosage of the control group was 1.0 mg/d, the research group A was 1.5 mg/d,and the research group B was 2.0 mg/d.The difference for blood sugar,clinical efficacy and adverse reactions of three groups was compared. Re-sults FINS,HOMA-β,HOMA-IR level and the mean time of blood sugar of three groups had no statistical significance (P>0.05).The incidence rate of hypoglycemia in the research group B was 21.88%,which was higher than that of the control group (0),which had statistical significance (P<0.05).FBG and 2 h PG of the control group after treatment was higher than that of the research group A and B,which had statistical significance (P<0.05). Conclusion The best dosage of repaglinide for patients with type 2 diabetes mellitus everyday is 1.0 mg,which can effectively control blood sugar and reduce the risk of hypoglycemia.