中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
24期
115-117
,共3页
胃出血%胃溃疡%铝碳酸镁%奥美拉唑
胃齣血%胃潰瘍%鋁碳痠鎂%奧美拉唑
위출혈%위궤양%려탄산미%오미랍서
Gastrorrhagia%Gastric ulcer%Hydrotalcite%Omeprazole
目的：探究奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血的临床效果及安全性。方法选取2013年1~12月本院收治的88例胃溃疡合并胃出血患者，按治疗方法分为观察组和对照组，每组各44例。观察组采用奥美拉唑联合铝碳酸镁治疗，对照组采用奥美拉唑治疗，比较两组的总有效率、幽门螺杆菌(Hp)根除率、复发率、不良反应发生率及症状评分。结果观察组的复发率显著低于对照组，Hp根除率显著高于对照组(P<0.05)，观察组、对照组的不良反应发生率分别为13.6%、11.4%，两组比较，差异无统计学意义(P>0.05)；观察组、对照组的总有效率分别为88.6%、63.6%，两组比较，差异有统计学意义(P<0.05)；治疗后，两组的症状评分均有所下降，观察组治疗后的症状评分显著低于对照组(P<0.05)。结论奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血临床效果确切，可靠安全，值得临床推广。
目的：探究奧美拉唑聯閤鋁碳痠鎂治療胃潰瘍閤併胃齣血的臨床效果及安全性。方法選取2013年1~12月本院收治的88例胃潰瘍閤併胃齣血患者，按治療方法分為觀察組和對照組，每組各44例。觀察組採用奧美拉唑聯閤鋁碳痠鎂治療，對照組採用奧美拉唑治療，比較兩組的總有效率、幽門螺桿菌(Hp)根除率、複髮率、不良反應髮生率及癥狀評分。結果觀察組的複髮率顯著低于對照組，Hp根除率顯著高于對照組(P<0.05)，觀察組、對照組的不良反應髮生率分彆為13.6%、11.4%，兩組比較，差異無統計學意義(P>0.05)；觀察組、對照組的總有效率分彆為88.6%、63.6%，兩組比較，差異有統計學意義(P<0.05)；治療後，兩組的癥狀評分均有所下降，觀察組治療後的癥狀評分顯著低于對照組(P<0.05)。結論奧美拉唑聯閤鋁碳痠鎂治療胃潰瘍閤併胃齣血臨床效果確切，可靠安全，值得臨床推廣。
목적：탐구오미랍서연합려탄산미치료위궤양합병위출혈적림상효과급안전성。방법선취2013년1~12월본원수치적88례위궤양합병위출혈환자，안치료방법분위관찰조화대조조，매조각44례。관찰조채용오미랍서연합려탄산미치료，대조조채용오미랍서치료，비교량조적총유효솔、유문라간균(Hp)근제솔、복발솔、불량반응발생솔급증상평분。결과관찰조적복발솔현저저우대조조，Hp근제솔현저고우대조조(P<0.05)，관찰조、대조조적불량반응발생솔분별위13.6%、11.4%，량조비교，차이무통계학의의(P>0.05)；관찰조、대조조적총유효솔분별위88.6%、63.6%，량조비교，차이유통계학의의(P<0.05)；치료후，량조적증상평분균유소하강，관찰조치료후적증상평분현저저우대조조(P<0.05)。결론오미랍서연합려탄산미치료위궤양합병위출혈림상효과학절，가고안전，치득림상추엄。
Objective To explore the clinical effect and safety of omeprazole combined with hydrotalcite in the treat-ment of gastric ulcer complicated with gastrorrhagia. Methods 88 patients with gastric ulcer complicated with gastror-rhagia admitted into our hospital from January to December 2013 were evenly divided into the observation group and the control group according to different therapeutic methods.The observation group was treated with omeprazole com-bined with hydrotalcite,while in the control group,only omeprazole was applied.The total effective rate,eradication rate of helicobacter pylori (Hp),recurrence rate, incidence rate of adverse reaction,and symptom score after therapy were com-pared in the two groups. Results In the observation group,the recurrence rate was greatly lower than that in the control group,the eradication rate of Hp in the observation group was obviously higher in comparison with that in the control group (P<0.05). The incidence rate of adverse reaction in the observation group and control group was 13.6% and 11.4%respectively,but didn't show statistical difference (P>0.05). The total effective rate in the observation group and control group was 88.6% and 63.6% respectively with a statistical difference (P<0.05).After treatment,symptom score in the two groups both decreased,and symptom score in the observation group was remarkably lower than that in the con-trol group with a statistical difference (P<0.05). Conclusion Omeprazole combined with hydrotalcite in the treatment of gastric ulcer complicated with gastrorrhagia can obtain a definite clinical effect.It is reliable and safe,and is worthy of expansion in clinic.
