中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
24期
88-90
,共3页
米索前列醇%缩宫素%宫颈成熟%引产
米索前列醇%縮宮素%宮頸成熟%引產
미색전렬순%축궁소%궁경성숙%인산
Misoprostol%Oxytocin%Cervical ripening%Induced labor
目的：探讨小剂量米索前列醇片对晚期妊娠引产的有效性及安全性。方法100例妊娠≥38周宫颈评分2~6分的单胎头位初产妇分成米索组与缩宫素组，每组各50例。米索组应用米索前列醇25μg (1/8片)，置于阴道后穹隆，6 h后未临产可重复给药1次，一日最大量≤50μg；缩宫素组应用0.5%或1%缩宫素持续静脉滴注，6~8 h/d，最多不超过72 h。比较两组的引产效果、第1次用药至临产的时间、总产程时间、剖宫产率。结果米索组的引产成功率高于缩宫素组(P<0.05)。米索组引产前宫颈评分2~4分(包括4分)的引产有效率为89.3%，高于缩宫素组的32.0%(P<0.05)。米索组的第1次用药至临产的时间明显短于缩宫素组(P<0.01)，米索组的剖宫产率显著低于缩宫素组(P<0.01)。结论小剂量米索前列醇(25μg/次)阴道给药用于晚期妊娠引产促宫颈成熟的效果肯定，易被产妇接受，副作用小，值得临床推广，尤其是对于有阴道分娩条件而宫颈条件不成熟者更有优越性。
目的：探討小劑量米索前列醇片對晚期妊娠引產的有效性及安全性。方法100例妊娠≥38週宮頸評分2~6分的單胎頭位初產婦分成米索組與縮宮素組，每組各50例。米索組應用米索前列醇25μg (1/8片)，置于陰道後穹隆，6 h後未臨產可重複給藥1次，一日最大量≤50μg；縮宮素組應用0.5%或1%縮宮素持續靜脈滴註，6~8 h/d，最多不超過72 h。比較兩組的引產效果、第1次用藥至臨產的時間、總產程時間、剖宮產率。結果米索組的引產成功率高于縮宮素組(P<0.05)。米索組引產前宮頸評分2~4分(包括4分)的引產有效率為89.3%，高于縮宮素組的32.0%(P<0.05)。米索組的第1次用藥至臨產的時間明顯短于縮宮素組(P<0.01)，米索組的剖宮產率顯著低于縮宮素組(P<0.01)。結論小劑量米索前列醇(25μg/次)陰道給藥用于晚期妊娠引產促宮頸成熟的效果肯定，易被產婦接受，副作用小，值得臨床推廣，尤其是對于有陰道分娩條件而宮頸條件不成熟者更有優越性。
목적：탐토소제량미색전렬순편대만기임신인산적유효성급안전성。방법100례임신≥38주궁경평분2~6분적단태두위초산부분성미색조여축궁소조，매조각50례。미색조응용미색전렬순25μg (1/8편)，치우음도후궁륭，6 h후미임산가중복급약1차，일일최대량≤50μg；축궁소조응용0.5%혹1%축궁소지속정맥적주，6~8 h/d，최다불초과72 h。비교량조적인산효과、제1차용약지임산적시간、총산정시간、부궁산솔。결과미색조적인산성공솔고우축궁소조(P<0.05)。미색조인산전궁경평분2~4분(포괄4분)적인산유효솔위89.3%，고우축궁소조적32.0%(P<0.05)。미색조적제1차용약지임산적시간명현단우축궁소조(P<0.01)，미색조적부궁산솔현저저우축궁소조(P<0.01)。결론소제량미색전렬순(25μg/차)음도급약용우만기임신인산촉궁경성숙적효과긍정，역피산부접수，부작용소，치득림상추엄，우기시대우유음도분면조건이궁경조건불성숙자경유우월성。
Objective To explore the efficacy and safety of small dose of misoprostol tablet to the induced labor for late pregnancy. Methods 100 pregnant women ( pregnancy≥38 weeks,and cervical ripeness score 2-6 points) with single birth and first gestation were divided into the misoprostol group (n=50) and the oxytocin group (n=50).The misoprostol group was given misoprostol 25μg (1/8 tablet) placed in the posterior fornix of vagina,after 6 hours,it was not in labor,pa-tients could be repeatedly administered 1 time.and a day the most ≤50 μ g;the oxytocin group was given 0.5% or 1%oxytocin for continue intravenous infusion,6-8 h/d,up to a maximum of 72 h. Induction effect,the time of from the first dose to labor,total labor time,the rate of cesarean section of the two groups were compared. Results The induction suc-cess rate in the misoprostol group was higher than that in the oxytocin group (P<0.05).The effective rate of induction of in the misoprostol group [labor beforecervical score 2-4 points (including 4 points)] (89.3%) was higher than that of the oxytocin group (32%) (P<0.05).The time of from the first dose to labor in the misoprostol group was obviously shorter than that in the oxytocin group (P<0.01).Cesarean section rate in the misoprostol group was significantly lower than that of the oxytocin group (P<0.01). Conclusion The effect of a small dose of misoprostol (25μg every time) with vaginal administration for promoting cervical ripening in late pregnancy women is sure,it is easy to be accepted by puerperae with little side effect,and it is worthy of clinical promotion,especially it is superior for patients having vaginal delivery conditions with immature cervical conditions.
