CAJ | 학술논문

目的：研究无创正压通气联合纳洛酮对慢性阻塞性肺病(COPD)呼吸衰竭患者氧代谢及肺功能的影响。方法选取2011年12月~2013年9月入住本院的68例COPD呼吸衰竭患者作为研究对象，按随机双盲法分组，实验组应用无创正压通气联合纳洛酮治疗，对照组单纯应用无创正压通气治疗，治疗3d后，对比两组的治疗效果。结果与治疗前相比，两组病情均有所改善，实验组氧代谢指标、肺通气功能、肺换气功能改善优于对照组，差异有统计学意义(P<0.05)。结论无创正压通气联合纳洛酮在COPD呼吸衰竭患者中具有较高的临床应用价值，值得推广应用。
목적：연구무창정압통기연합납락동대만성조새성폐병(COPD)호흡쇠갈환자양대사급폐공능적영향。방법선취2011년12월~2013년9월입주본원적68례COPD호흡쇠갈환자작위연구대상，안수궤쌍맹법분조，실험조응용무창정압통기연합납락동치료，대조조단순응용무창정압통기치료，치료3d후，대비량조적치료효과。결과여치료전상비，량조병정균유소개선，실험조양대사지표、폐통기공능、폐환기공능개선우우대조조，차이유통계학의의(P<0.05)。결론무창정압통기연합납락동재COPD호흡쇠갈환자중구유교고적림상응용개치，치득추엄응용。
Objective To research influence of non-invasive positive pressure ventilation combined with naloxone on oxygen metabolism and pulmonary function in chronic obstructive pulmonary disease (COPD)patients with respiratory failure. Methods Sixty-eight COPD patients with respiratory failure in our hospital from December 2011 to September 2013 were selected and divided into two group by random and double blind.The experimental group was treated by non-invasive positive pressure ventilation combined with naloxone,the control group was only treated by non-invasive positive pressure ventilation.After 3-day of treatment,the therapeutic effect of two groups was compared. Results The disease condition in two groups after therapy was improved in comparison with that before treatment respectively,the in-dex of oxygen metabolism,pulmonary ventilation function and pulmonary gas exchange function in the experimental group was superior than that in the control group respectively,with statistical difference(P<0.05). Conclusion Combina-tion of non-invasive positive pressure ventilation and naloxone can obtain a high clinical application value in the treat-ment of COPD with pulmonary failure,and it is worthy of promotion and application.