中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
24期
27-29
,共3页
万方锐%黄娟%张江华%吴海霞%章燕燕%吴冬
萬方銳%黃娟%張江華%吳海霞%章燕燕%吳鼕
만방예%황연%장강화%오해하%장연연%오동
儿童%传染性单核细胞增多症%肝损害%特征
兒童%傳染性單覈細胞增多癥%肝損害%特徵
인동%전염성단핵세포증다증%간손해%특정
Children%Infectious mononucleosis%Hepatic lesion%Characteristics
目的:探讨儿童传染性单核细胞增多症并发肝损害的临床特点。方法按照是否并发肝损害将本院收治的112例传染性单核细胞增多症患儿分为肝损害组(32例)和非肝损害组(80例),比较两组患儿的临床症状特点、外周血主要指标水平以及肝功能相关指标变化情况。结果肝损害组患儿肝大和脾大的发生率均显著高于非肝损害组,咽峡炎、浅表淋巴结肿大和皮疹的发生率均显著低于非肝损害组,差异有统计学意义(P<0.05);肝损害组患儿血小板计数(PLT)<100×109/L和异型淋巴细胞>10%的发生率均显著高于非肝损害组,差异有统计学意义(P<0.05);肝损害组患儿天冬氨酸氨基转移酶(AST)升高、丙氨酸氨基转移酶(ALT)升高、直接胆红素(DBiL)升高、总胆红素(TBiL)升高、乳酸脱氢酶(LDH-L)升高、谷氨酰转移酶(GGT)升高、白蛋白(Alb)降低的发生率均显著高于非肝损害组,差异有统计学意义(P<0.05)。结论儿童传染性单核细胞增多症并发肝损害以持续性发热、中重度肝脾大、肝酶异常、血小板减少和异形淋巴细胞增加为主要临床特征,当患儿肝功能明显受损时,应及时确诊并采取有效治疗措施。
目的:探討兒童傳染性單覈細胞增多癥併髮肝損害的臨床特點。方法按照是否併髮肝損害將本院收治的112例傳染性單覈細胞增多癥患兒分為肝損害組(32例)和非肝損害組(80例),比較兩組患兒的臨床癥狀特點、外週血主要指標水平以及肝功能相關指標變化情況。結果肝損害組患兒肝大和脾大的髮生率均顯著高于非肝損害組,嚥峽炎、淺錶淋巴結腫大和皮疹的髮生率均顯著低于非肝損害組,差異有統計學意義(P<0.05);肝損害組患兒血小闆計數(PLT)<100×109/L和異型淋巴細胞>10%的髮生率均顯著高于非肝損害組,差異有統計學意義(P<0.05);肝損害組患兒天鼕氨痠氨基轉移酶(AST)升高、丙氨痠氨基轉移酶(ALT)升高、直接膽紅素(DBiL)升高、總膽紅素(TBiL)升高、乳痠脫氫酶(LDH-L)升高、穀氨酰轉移酶(GGT)升高、白蛋白(Alb)降低的髮生率均顯著高于非肝損害組,差異有統計學意義(P<0.05)。結論兒童傳染性單覈細胞增多癥併髮肝損害以持續性髮熱、中重度肝脾大、肝酶異常、血小闆減少和異形淋巴細胞增加為主要臨床特徵,噹患兒肝功能明顯受損時,應及時確診併採取有效治療措施。
목적:탐토인동전염성단핵세포증다증병발간손해적림상특점。방법안조시부병발간손해장본원수치적112례전염성단핵세포증다증환인분위간손해조(32례)화비간손해조(80례),비교량조환인적림상증상특점、외주혈주요지표수평이급간공능상관지표변화정황。결과간손해조환인간대화비대적발생솔균현저고우비간손해조,인협염、천표림파결종대화피진적발생솔균현저저우비간손해조,차이유통계학의의(P<0.05);간손해조환인혈소판계수(PLT)<100×109/L화이형림파세포>10%적발생솔균현저고우비간손해조,차이유통계학의의(P<0.05);간손해조환인천동안산안기전이매(AST)승고、병안산안기전이매(ALT)승고、직접담홍소(DBiL)승고、총담홍소(TBiL)승고、유산탈경매(LDH-L)승고、곡안선전이매(GGT)승고、백단백(Alb)강저적발생솔균현저고우비간손해조,차이유통계학의의(P<0.05)。결론인동전염성단핵세포증다증병발간손해이지속성발열、중중도간비대、간매이상、혈소판감소화이형림파세포증가위주요림상특정,당환인간공능명현수손시,응급시학진병채취유효치료조시。
Objective To explore the clinical characteristics of children infectious mononucleosis complicated with hep-atic lesion. Methods 112 children with infectious mononucleosis,based on whether they were complicated with hepatic lesion,were allocated to hepatic lesion group (32 patients) and non-hepatic lesion group (80 patients).Characteristics of clinical symptoms,levels of main indices of peripheral blood and changes of indices of hepatic functions were compared between the two groups. Results Incidences of hepatomegaly and splenomegaly in the hepatic lesion group were higher than those in the non-hepatic lesion group,and incidences of angina,superficial lymph node enlargement and skin rash were lower than those in the non-hepatic lesion group,the differences were significant (P<0.05);incidences of PLT<100í109/L and atypical lymphocytes>10% in the hepatic lesion group were higher than those in the non-hepatic lesion group,the differences were significant (P<0.05);incidences of increased AST,increased ALT,increased DBiL,increased TBiL,increased LDH-L,increased GGT and decreased Alb were all higher than those in the non-hepatic lesion group, the differences were significant (P<0.05). Conclusion The main clinical characteristics of children infectious mononu-cleosis complicated with hepatic lesion are persistent fever,moderate and severe hepatomegaly and splenomegaly,abnor-mal hepatic enzyme,thrombocytopenia and increased atypical lymphocytes.When obvious damaged hepatic functions are shown in children patients,it is necessary to carry out timely diagnosis and effective treatment.