CAJ | 학술논문

目的：探讨舒肝解郁胶囊联合帕罗西汀治疗老年抑郁症的疗效。方法将90例老年抑郁症患者随机分为治疗组和对照组各45例。治疗组用舒肝解郁胶囊联合帕罗西汀治疗，对照组单用帕罗西汀治疗。采用汉密尔顿抑郁量表（HAMD）及汉密尔顿焦虑量表（HAMA）评定疗效。结果治疗6周末治疗组总有效率为86.7%高于对照组的66.7%，差异有统计学意义（P ﹤0.05）。治疗后2组 HAMD 和 HAMA 评分均逐渐降低，6周后均较治疗前下降，差异有统计学意义（P ﹤0.01）。在第1、2周末2组 HAMD 和 HAMA 评分比较差异无统计学意义（P ﹥0.05），第4、6周末治疗组 HAMD 和 HAMA 评分低于对照组，差异均有统计学意义（P ﹤0.01）。结论舒肝解郁胶囊联合帕罗西汀治疗老年抑郁症有较好的临床疗效，且不良反应较小，有一定的临床应用价值。
목적：탐토서간해욱효낭연합파라서정치료노년억욱증적료효。방법장90례노년억욱증환자수궤분위치료조화대조조각45례。치료조용서간해욱효낭연합파라서정치료，대조조단용파라서정치료。채용한밀이돈억욱량표（HAMD）급한밀이돈초필량표（HAMA）평정료효。결과치료6주말치료조총유효솔위86.7%고우대조조적66.7%，차이유통계학의의（P ﹤0.05）。치료후2조 HAMD 화 HAMA 평분균축점강저，6주후균교치료전하강，차이유통계학의의（P ﹤0.01）。재제1、2주말2조 HAMD 화 HAMA 평분비교차이무통계학의의（P ﹥0.05），제4、6주말치료조 HAMD 화 HAMA 평분저우대조조，차이균유통계학의의（P ﹤0.01）。결론서간해욱효낭연합파라서정치료노년억욱증유교호적림상료효，차불량반응교소，유일정적림상응용개치。
Objective To discuss the effect of shuganjieyu capsule combined with paroxetine in the treatment of se-nile depression. Methods 90 cases of patients with senile depression were randomly divided into treatment group and control group,esch of 45 cases. Treatment group was treated with shuganjieyu capsule combined with paroxetine. Control group was treated with paroxetine alone. The Hamilton Depression Rating Scale(HAMD)and the Hamilton Anxiety Scale(HAMA)were used to observe the effectiveness. Results After 6 weeks treatment,the total effective rate of treatment group was 86. 7% higer than 66. 7% of control group,the difference was statistically significant(P ﹤ 0. 05);the HAMD and HAMA scores were de-creased in both groups,compared with before treatment,the difference was statistically significant(P ﹤ 0. 01). In the first and second weekend,the difference of the HAMD and HAMA scores between the two groups was no statistically significant(P ﹥0. 05). In the fourth and sixth weedend,the HAMD and HAMA scores of treatment group were both lower than control group, the difference was statistically significant(P ﹤ 0. 01). Conclusion The treatment of shugan jieyu capsule combined with par-oxetine in senile epression has better clinical efficacy and less adverse reactions,has some clinical value.