CAJ | 학술논문

目的：检测CD24蛋白在鼻窦癌组织中表达的情况，探讨其与临床病理参数的关系及对鼻窦癌预后的临床意义。方法应用免疫组织化学方法检测26例鼻窦癌组织中CD24的表达情况并分析CD24与鼻窦癌临床病理特征及预后的关系。结果 CD24在鼻窦癌组织中的阳性表达率明显高于癌旁组织。CD24在鼻窦癌的阳性表达与患者的年龄、性别、肿瘤分型、组织学分级无关，而与淋巴结转移、临床分期正相关；CD24是影响鼻窦癌预后的独立预后因素。结论CD24表达可能提示鼻窦癌发展的恶性进程，其高表达提示鼻窦癌患者预后不良，有望成为一个新的相对独立的鼻窦癌患者生存的预后指标。
목적：검측CD24단백재비두암조직중표체적정황，탐토기여림상병리삼수적관계급대비두암예후적림상의의。방법응용면역조직화학방법검측26례비두암조직중CD24적표체정황병분석CD24여비두암림상병리특정급예후적관계。결과 CD24재비두암조직중적양성표체솔명현고우암방조직。CD24재비두암적양성표체여환자적년령、성별、종류분형、조직학분급무관，이여림파결전이、림상분기정상관；CD24시영향비두암예후적독립예후인소。결론CD24표체가능제시비두암발전적악성진정，기고표체제시비두암환자예후불량，유망성위일개신적상대독립적비두암환자생존적예후지표。
ObjectiveTo study the significance of CD24 protein expressions in human paranasal sinus carcinoma and their relationship with clinical pathological parameters and clinical prognosis.Methods The expressions of CD24 protein were studied in 26 paranasal sinus carcinoma samples by Elivision immunohistochemical (IHC) analysis and the relationships of CD24 with clinical pathological parameters and prognosis were also explored.Results The expression of CD24 in paranasal sinus carcinoma was signiifcantly higher than that in adjacent normal tissues. The expression of CD24 was not related with the age of patient, sexuality, tumor type, histologic grade, but there was a positive correlation with the lymphnode metastasis and the clinical stage of tumor and CD24 was an independent prognostic factor for paranasal sinus carcinoma prognosis.Conclusion CD24 may be related to the malignant process of paranasal sinus carcinoma. Over expression of CD24 indicates poor prognosis in paranasal sinus carcinoma patients. CD24 may become a new prognostic marker for paranasal sinus carcinoma.