CAJ | 학술논문

目的：探讨急性心肌梗死(AMI)患者早期脑钠肽(BNP)水平与近期预后的关系。方法选择2011年10月～2013年3月四川省仁寿县人民医院86例AMI患者。入院时测定BNP浓度，根据早期血浆BNP水平分为A、B、C组，分别为BNP<800 pg/mL、800～8000 pg/mL、>8000 pg/mL。比较不同BNP水平组3个月内患者因心衰再入院治疗的患者人次数，以及随访结束时生存情况和再次心脏彩超测得左室射血分数(LVEF)和舒张末期内径(LVED)，并进一步计算出ΔLVED，ΔLVED=(恢复期LVEDV-急性期LVEDV)/急性期LVEDV。结果 C组因心衰再入院率和死亡率高于A、B组，差异均有统计学意义(P<0.05)，但A、B组间差异无统计学差异。随着BNP水平升高，LVEF逐渐降低，ΔLVED逐渐升高，3组间两两比较差异有统计学意义(P<0.05)。结论 AMI患者血浆BNP>8000pg/mL，3个月内因心衰再入院治疗和死亡的可能性增加。血浆BNP水平越高，左室心肌收缩能力损害和心室重塑程度越重。血浆BNP水平可以为AMI患者近期预后提供有用的信息。
목적：탐토급성심기경사(AMI)환자조기뇌납태(BNP)수평여근기예후적관계。방법선택2011년10월～2013년3월사천성인수현인민의원86례AMI환자。입원시측정BNP농도，근거조기혈장BNP수평분위A、B、C조，분별위BNP<800 pg/mL、800～8000 pg/mL、>8000 pg/mL。비교불동BNP수평조3개월내환자인심쇠재입원치료적환자인차수，이급수방결속시생존정황화재차심장채초측득좌실사혈분수(LVEF)화서장말기내경(LVED)，병진일보계산출ΔLVED，ΔLVED=(회복기LVEDV-급성기LVEDV)/급성기LVEDV。결과 C조인심쇠재입원솔화사망솔고우A、B조，차이균유통계학의의(P<0.05)，단A、B조간차이무통계학차이。수착BNP수평승고，LVEF축점강저，ΔLVED축점승고，3조간량량비교차이유통계학의의(P<0.05)。결론 AMI환자혈장BNP>8000pg/mL，3개월내인심쇠재입원치료화사망적가능성증가。혈장BNP수평월고，좌실심기수축능력손해화심실중소정도월중。혈장BNP수평가이위AMI환자근기예후제공유용적신식。
Objective To examine the correlation of plasma brain natriuretic peptide(BNP) with short-term prognosis in acute myocardial infarction(AMI).Methods A total of 86 AMI patients were divided based on the plasma BNP level: BNP<800pg/mL (group A), 800~8000pg/mL (group B), >8000pg/mL (group C) respectively. Readmission rate, mortality within 3 months for heart failure, as well as left ventricular ejection fraction(LVEF) and left ventricular end diastolic diameter(ΔLVED) at ifnal follow up measured by echocardiography were compared between the three groups.Results AMI patients in group C had significantly higher readmission rate, mortality within 3 months than those in group A and B(P<0.05). However, there was no signiifcant difference between group A and B. The higher BNP level was, the lower LVEF was, the higher ΔLVED was(P<0.05).Conclusion The levels of plasma BNP are associated with readmission rate, mortality within 3 months, LVEF and ΔLVED, so it can be used in predicting short-term prognosis of AMI.