CAJ | 학술논문

目的：探讨不同阶梯浓度的庆大霉素明胶海绵浆治疗顽固性梅尼埃病的临床意义。方法对7例诊断为顽固性梅尼埃病患者并经过常规鼓室注射庆大霉素治疗无效后，通过鼓室内多次注入不同阶梯浓度的庆大霉素明胶海绵浆进行化学性迷路切除，观察治疗后眩晕发作、耳鸣情况、听力变化及并发症。结果7例中，眩晕3例得到完全控制，3例得到明显缓解，1例无效；耳鸣1例消失，5例缓解，1例无效；听力1例提高，1例加重，其余5例无明显变化。随访1年未发现有鼓膜穿孔。结论该方法可能是治疗顽固性梅尼埃病的一种疗效稳定，安全可靠的新方法。
목적：탐토불동계제농도적경대매소명효해면장치료완고성매니애병적림상의의。방법대7례진단위완고성매니애병환자병경과상규고실주사경대매소치료무효후，통과고실내다차주입불동계제농도적경대매소명효해면장진행화학성미로절제，관찰치료후현훈발작、이명정황、은력변화급병발증。결과7례중，현훈3례득도완전공제，3례득도명현완해，1례무효；이명1례소실，5례완해，1례무효；은력1례제고，1례가중，기여5례무명현변화。수방1년미발현유고막천공。결론해방법가능시치료완고성매니애병적일충료효은정，안전가고적신방법。
Objective To dicuss the clinical value in the treatment of modified chemical laby-rinthectomy in intractable Meniere's disease by repeatedly transtympanic injecting low concentrations of gentamicin gelatin sponge mud . Methods Seven subjects with intractable Meniere's disease were includ-ed in this study . Transtympanic low concentrations of gentamicin gelatin sponge mud injecting was taken repeatedly after Ineffective conventional intratympanic gentamyci therapy . he onset of vertigo ,tinni-tus ,hearing change ,and complications were observed after treatment . Results In 7 cases ,complete re-lief vertigo was maintained in 3 cases ,reduced in 3 cases ,unchanged in 1 cases ,and complete relief tinitus was maintained in 1cases ,reduced in 5 cases ,unchanged in 1 cases ,No complications ,such as tympanic membrane perforation or infection were observed . Conclusion Transtympanic repeatedly injecting low concentrations of gentamicin gelatin sponge mud may be a new safe ,reliable modified treatment of intracta-ble M eniere's disease .