中西医结合肝病杂志
中西醫結閤肝病雜誌
중서의결합간병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE ON LIVER DISEASES
2014年
4期
200-202,206
,共4页
程晶%唐海鸿%李群%邢宇锋%陈亮%张来%占伯林%贺劲松%周大桥
程晶%唐海鴻%李群%邢宇鋒%陳亮%張來%佔伯林%賀勁鬆%週大橋
정정%당해홍%리군%형우봉%진량%장래%점백림%하경송%주대교
补肾解毒健脾冲剂/治疗应用%慢性乙肝病毒携带者%乙型肝炎e抗原%乙肝病毒脱氧核糖核酸%肝组织学
補腎解毒健脾遲劑/治療應用%慢性乙肝病毒攜帶者%乙型肝炎e抗原%乙肝病毒脫氧覈糖覈痠%肝組織學
보신해독건비충제/치료응용%만성을간병독휴대자%을형간염e항원%을간병독탈양핵당핵산%간조직학
Bushen Jiedu Jianpi granule/theraputic application%chronic hepatitis B virus carriers%HBeAg%HBV DNA%liver histology
目的：研讨验证补肾解毒健脾冲剂对慢性乙肝病毒携带者HBV DNA、 HBeAg和肝组织学的作用。方法：筛选慢性乙肝病毒携带者200例，以1∶1的比例随机分为治疗组和对照组。治疗组用补肾解毒健脾冲剂治疗，对照组用安慰剂干预，周期为72周。结果：治疗72周后，治疗组患者血清HBV DNA下降﹥1 log10、﹥2 log10及﹥3 log10的患者比例明显高于对照组（P﹤0.005）。治疗组患者血清HBeAg阴转率及转换率明显高于对照组，两组比较差异有统计学意义（P﹤0.05）。治疗组患者治疗前后肝组织的炎症活动度分级及纤维化程度分期相比差异有统计学意义（P﹤0.05），72周时，与对照组比较，差异有统计学意义（P﹤0.05）。结论：补肾解毒健脾冲剂对慢性乙肝病毒携带者的HBeAg血清学转换及HBV DNA阴转作用明显，对肝脏组织炎症活动度及纤维化程度也有改善作用，安全性好，未见明显副作用。
目的：研討驗證補腎解毒健脾遲劑對慢性乙肝病毒攜帶者HBV DNA、 HBeAg和肝組織學的作用。方法：篩選慢性乙肝病毒攜帶者200例，以1∶1的比例隨機分為治療組和對照組。治療組用補腎解毒健脾遲劑治療，對照組用安慰劑榦預，週期為72週。結果：治療72週後，治療組患者血清HBV DNA下降﹥1 log10、﹥2 log10及﹥3 log10的患者比例明顯高于對照組（P﹤0.005）。治療組患者血清HBeAg陰轉率及轉換率明顯高于對照組，兩組比較差異有統計學意義（P﹤0.05）。治療組患者治療前後肝組織的炎癥活動度分級及纖維化程度分期相比差異有統計學意義（P﹤0.05），72週時，與對照組比較，差異有統計學意義（P﹤0.05）。結論：補腎解毒健脾遲劑對慢性乙肝病毒攜帶者的HBeAg血清學轉換及HBV DNA陰轉作用明顯，對肝髒組織炎癥活動度及纖維化程度也有改善作用，安全性好，未見明顯副作用。
목적：연토험증보신해독건비충제대만성을간병독휴대자HBV DNA、 HBeAg화간조직학적작용。방법：사선만성을간병독휴대자200례，이1∶1적비례수궤분위치료조화대조조。치료조용보신해독건비충제치료，대조조용안위제간예，주기위72주。결과：치료72주후，치료조환자혈청HBV DNA하강﹥1 log10、﹥2 log10급﹥3 log10적환자비례명현고우대조조（P﹤0.005）。치료조환자혈청HBeAg음전솔급전환솔명현고우대조조，량조비교차이유통계학의의（P﹤0.05）。치료조환자치료전후간조직적염증활동도분급급섬유화정도분기상비차이유통계학의의（P﹤0.05），72주시，여대조조비교，차이유통계학의의（P﹤0.05）。결론：보신해독건비충제대만성을간병독휴대자적HBeAg혈청학전환급HBV DNA음전작용명현，대간장조직염증활동도급섬유화정도야유개선작용，안전성호，미견명현부작용。
Objective: To investigate the effect of Bushen Jiedu Jianpi granule on HBV DNA , HBeAg and liver histology of chronic hepatitis B virus carriers.Methods: A total of 200 chronic HBV carriers diagnosed according to the diagnostic standard of chronic hepatitis B carriers were randomly divided into 2 groups, a treatment group and a control group.The treatment group re-ceived Bushen Jiedu Jianpi granule , and the control group was given placebo.The duration of treatment was 72 weeks.Results:After 72 weeks, the proportions of patients in the treatment group in whom serum HBV DNA levels decreased by more than 1 log10 , 2 log10, and 3 log10 were significantly higher than those in the control group (P﹤0.005) .The HBeAg seroconversion rate and the negative conversion rate of serum HBV DNA in the treatment group were significantly higher than those of the control group ( P﹤0.05) .The inflammatory activity grade and fibrosis stage in the treatment group got better after treatment (P﹤0.05) .Con-clusion: Bushen Jiedu Jianpi granule have improve HBeAg seroconversion rate , inhibite the HBV DNA replication and also relieve the liver tissue inflammation and degree of fibrosis stages.The clinical observation showed better security.
