中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
4期
24-26
,共3页
卵巢癌%肿瘤分子标记物%联合动态检测%监控
卵巢癌%腫瘤分子標記物%聯閤動態檢測%鑑控
란소암%종류분자표기물%연합동태검측%감공
Ovarian cancer%Tumor molecular markers%The joint dynamic detection%Monitoring
目的：探讨血清肿瘤分子标记物糖类抗原（CA125）、癌胚抗原（CEA）、人附睾蛋白4（HE4）、恶性肿瘤特异性生长因子（TSGF）联合动态监测诊断卵巢癌的临床应用价值。方法选取2011年1月至2013年12月日照市人民医院收治的100例卵巢癌患者作为观察组，另选30例卵巢良性病变患者作为对照组，两组患者均经术后病理学确诊。采用电化学发光法检测患者血清 CA125、CEA，ELISA 法检测 HE4，化学比色法检测 TSGF 水平，分析血清肿瘤分子标记物与卵巢良恶性肿瘤的相关性。结果观察组患者血清 CA125、CEA、HE4、TSGF 水平明显高于对照组（P<0.01）；卵巢癌高分期组（Ⅲ、Ⅳ期）明显高于低分期组（Ⅰ、Ⅱ期），淋巴结转移明显高于无转移者，复发者明显高于无复发者（均 P<0.01）；术后1周明显低于术前（P<0.01）；4项肿瘤分子标记物联合检测诊断卵巢癌的敏感性、准确性、阴性预测值明显高于单项检测（P<0.01）。结论血清 CA125、CEA、HE4、TSGF 水平与卵巢癌临床分期、复发及转移相关，联合检测可提高卵巢癌诊断的敏感性、准确性、阴性预测值，同时联合动态监测对监控治疗、复发、转移及随访具有临床指导意义。
目的：探討血清腫瘤分子標記物糖類抗原（CA125）、癌胚抗原（CEA）、人附睪蛋白4（HE4）、噁性腫瘤特異性生長因子（TSGF）聯閤動態鑑測診斷卵巢癌的臨床應用價值。方法選取2011年1月至2013年12月日照市人民醫院收治的100例卵巢癌患者作為觀察組，另選30例卵巢良性病變患者作為對照組，兩組患者均經術後病理學確診。採用電化學髮光法檢測患者血清 CA125、CEA，ELISA 法檢測 HE4，化學比色法檢測 TSGF 水平，分析血清腫瘤分子標記物與卵巢良噁性腫瘤的相關性。結果觀察組患者血清 CA125、CEA、HE4、TSGF 水平明顯高于對照組（P<0.01）；卵巢癌高分期組（Ⅲ、Ⅳ期）明顯高于低分期組（Ⅰ、Ⅱ期），淋巴結轉移明顯高于無轉移者，複髮者明顯高于無複髮者（均 P<0.01）；術後1週明顯低于術前（P<0.01）；4項腫瘤分子標記物聯閤檢測診斷卵巢癌的敏感性、準確性、陰性預測值明顯高于單項檢測（P<0.01）。結論血清 CA125、CEA、HE4、TSGF 水平與卵巢癌臨床分期、複髮及轉移相關，聯閤檢測可提高卵巢癌診斷的敏感性、準確性、陰性預測值，同時聯閤動態鑑測對鑑控治療、複髮、轉移及隨訪具有臨床指導意義。
목적：탐토혈청종류분자표기물당류항원（CA125）、암배항원（CEA）、인부고단백4（HE4）、악성종류특이성생장인자（TSGF）연합동태감측진단란소암적림상응용개치。방법선취2011년1월지2013년12월일조시인민의원수치적100례란소암환자작위관찰조，령선30례란소량성병변환자작위대조조，량조환자균경술후병이학학진。채용전화학발광법검측환자혈청 CA125、CEA，ELISA 법검측 HE4，화학비색법검측 TSGF 수평，분석혈청종류분자표기물여란소량악성종류적상관성。결과관찰조환자혈청 CA125、CEA、HE4、TSGF 수평명현고우대조조（P<0.01）；란소암고분기조（Ⅲ、Ⅳ기）명현고우저분기조（Ⅰ、Ⅱ기），림파결전이명현고우무전이자，복발자명현고우무복발자（균 P<0.01）；술후1주명현저우술전（P<0.01）；4항종류분자표기물연합검측진단란소암적민감성、준학성、음성예측치명현고우단항검측（P<0.01）。결론혈청 CA125、CEA、HE4、TSGF 수평여란소암림상분기、복발급전이상관，연합검측가제고란소암진단적민감성、준학성、음성예측치，동시연합동태감측대감공치료、복발、전이급수방구유림상지도의의。
Objective Explore the clinical value of serum tumor markers,such as carbohydrate antigens(CA125), carcinoembryonic antigen(CEA), human epididymis protein 4 (HE4), malignant tumor specific growth factor (TSGF),combined with dynamic monitoring for the diagnosis of ovarian cancer. Methods From January 2011 to December 2013,100 cases of ovarian cancer patients (observation group) and 30 cases of patients with ovarian benign lesions (control group) were selectd as the research object, both of them by postoperative pathological diagnosis.Electrochemical luminescence method to detect patients with serum CA125, CEA, ELISA method for detecting HE4, chemical colorimetry to detect levels of TSGF, then analyse the correlation of ovarian benign and malignant tumors with serum levels of tumor molecular markers. Results CA125, CEA, HE4, TSGF level of ovarian cancer patients were obviously higher than that of ovarian benign tumor lesion group(P<0.01);Ovarian cancer is high ( Ⅲ , Ⅳ ) staging group was obviously higher than that of low stage group ( Ⅰ , Ⅱ ), lymph node metastasis were significantly higher than those without metastasis,recurrence were significantly higher than the relapse-free(P<0.01);One week after operation was significantly lower than that before operation(P<0.01);Four joint tumor molecular markers to detect the sensitivity and accuracy of the diagnosis of ovarian cancer, negative predictive value is significantly higher than individual test(P<0.01). Conclusion Serum CA125, CEA, HE4, TSGF levels associated with ovarian cancer clinical stage, recurrence and metastasis, the joint detection can improve the sensitivity and accuracy of the diagnosis of ovarian cancer, negative predictive value, at the same time,he joint dynamic monitoring to monitor treatment, recurrence and metastasis and follow-up have clinical significance.
