CAJ | 학술논문

目的：探讨神经调节蛋白-1（NRG-1）干预对大鼠心肌梗死后低电压区起搏阈值的影响。方法：采用冠状动脉前降支结扎法建立心肌梗死大鼠模型，34只心肌梗死大鼠被随机均分为两组：NRG-1干预组（接受 NRG-1腹腔注射）和对照组（接受同体积生理盐水腹腔注射）。2周后测试大鼠心肌梗死后梗死相关的低电压区的起搏阈值，并检测低电压区 Cx43（连接蛋白家族的一种蛋白质）的表达。结果：药物干预2周时，NRG-1组起搏阈值明显低于对照组起搏阈值[（0.7167±0.194）V 比（1.466±0.503）V，P ＝0.002]；心肌梗死后低电压区 NRG-1组 Cx43表达较对照组明显增多[（0.95±0.20）比（0.30±0.15），P ＜0.001]。结论：NRG-1明显降低大鼠心肌梗死后低电压区起搏阈值，其机制可能与增加 Cx43表达，改善心肌细胞间电传导有关。
목적：탐토신경조절단백-1（NRG-1）간예대대서심기경사후저전압구기박역치적영향。방법：채용관상동맥전강지결찰법건립심기경사대서모형，34지심기경사대서피수궤균분위량조：NRG-1간예조（접수 NRG-1복강주사）화대조조（접수동체적생리염수복강주사）。2주후측시대서심기경사후경사상관적저전압구적기박역치，병검측저전압구 Cx43（련접단백가족적일충단백질）적표체。결과：약물간예2주시，NRG-1조기박역치명현저우대조조기박역치[（0.7167±0.194）V 비（1.466±0.503）V，P ＝0.002]；심기경사후저전압구 NRG-1조 Cx43표체교대조조명현증다[（0.95±0.20）비（0.30±0.15），P ＜0.001]。결론：NRG-1명현강저대서심기경사후저전압구기박역치，기궤제가능여증가 Cx43표체，개선심기세포간전전도유관。
Objective:To explore the influence of neuregulin- 1 (NRG-1)intervention on pacing threshold of low voltage area in rats after myocardial infarction.Methods:Myocardial infarction model of rat was established via an-terior descending coronary artery ligation.The 34 rats with myocardial infarction were randomly and averagely di-vided into two groups:NRG-1 group (received NRG-1peritoneal injection)and control group (received peritoneal injection of normal saline of the same volume).After two weeks,pacing thresholds were tested in low voltage area related with infarct in rats after myocardial infarction,and Cx43 (an integral membrane protein of the connexin family)expression was measured in low voltage area.Results:After drug intervention two weeks,compared with control group,there was significant reduction in pacing threshold [(1.466±0.503)V vs.(0.7167±0.194)V,P =0.002]in NRG-1 group;there was significant rise in Cx43 expression [(0.30±0.15)vs.(0.95±0.20),P <0.001] in low voltage area in NRG-1 group.Conclusion:Neuregulin-1 significantly reduces pacing threshold of low voltage area in rats after myocardial infarction,the mechanism may be related to increase Cx43 expression and improve e-lectrical conductivity of myocardial cells.