CAJ | 학술논문

目的：对比观察美沙拉嗪与柳氮磺胺吡啶治疗轻中度溃疡性结肠炎病人的疗效。方法采用随机对照研究方案，将入组的64例溃疡性结肠炎患者随机分为美沙拉嗪治疗组和柳氮磺胺吡啶治疗组，前者服用美沙拉嗪缓释颗粒剂，后者服用柳氮磺胺吡啶，疗程均为6周。记录治疗过程中出现的不良事件，根据改良Mayo评分系统评估两组治疗前后评分，判断治疗效果。结果美沙拉嗪治疗组有效率为90.6%，柳氮磺胺吡啶治疗组有效率为70.0%，两组有显著性差异（P<0.05）；美沙拉嗪治疗组不良事件发生率显著低于柳氮磺胺吡啶治疗组。结论美沙拉嗪治疗轻中度左半结肠型溃疡性结肠炎疗效显著而又安全。
목적：대비관찰미사랍진여류담광알필정치료경중도궤양성결장염병인적료효。방법채용수궤대조연구방안，장입조적64례궤양성결장염환자수궤분위미사랍진치료조화류담광알필정치료조，전자복용미사랍진완석과립제，후자복용류담광알필정，료정균위6주。기록치료과정중출현적불량사건，근거개량Mayo평분계통평고량조치료전후평분，판단치료효과。결과미사랍진치료조유효솔위90.6%，류담광알필정치료조유효솔위70.0%，량조유현저성차이（P<0.05）；미사랍진치료조불량사건발생솔현저저우류담광알필정치료조。결론미사랍진치료경중도좌반결장형궤양성결장염료효현저이우안전。
Objective To compare the effects of mesalazine and sulfasalazine for ulcerative colitis pa-tients. Methods patients with ulcerative colitis were randomly divided into treatment group and control group. Treatment group received mesalazine, and control group received sulfasalazine for a course of 6 weeks. The efficacy and adverse events of the two groups were observed. Results The total effective rate was 89.7.0%in treatment group which was significantly higher than 77.8%in control group (P<0.05). Adverse reaction rate was 5.1%in treatment group which was lower than 9.7%in control group, but the difference was not statisti-cally significant (P>0.05). Conclusion Sulfasalazine is effective in treatment of ulcerative colitis.