实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
JOURNAL OF PRACTICAL ONCOLOGY
2014年
4期
364-366
,共3页
宋春雨(综述)%曲国蕃(审校)
宋春雨(綜述)%麯國蕃(審校)
송춘우(종술)%곡국번(심교)
骨肉瘤%基因治疗%靶点
骨肉瘤%基因治療%靶點
골육류%기인치료%파점
Osteosarcoma%Gene-targeted therapy
骨肉瘤是临床未成年人骨骼系统常见的恶性骨肿瘤,新辅助化疗结合手术治疗提高了患者五年的生存率,但其病死率及致残率仍极高,随着分子生物学及遗传学的发展,基因治疗为骨肉瘤提供了新的希望,国内外研究人员积极地探索有效的治疗靶点,本文就骨肉瘤基因治疗靶点研究的新进展展开综述。
骨肉瘤是臨床未成年人骨骼繫統常見的噁性骨腫瘤,新輔助化療結閤手術治療提高瞭患者五年的生存率,但其病死率及緻殘率仍極高,隨著分子生物學及遺傳學的髮展,基因治療為骨肉瘤提供瞭新的希望,國內外研究人員積極地探索有效的治療靶點,本文就骨肉瘤基因治療靶點研究的新進展展開綜述。
골육류시림상미성년인골격계통상견적악성골종류,신보조화료결합수술치료제고료환자오년적생존솔,단기병사솔급치잔솔잉겁고,수착분자생물학급유전학적발전,기인치료위골육류제공료신적희망,국내외연구인원적겁지탐색유효적치료파점,본문취골육류기인치료파점연구적신진전전개종술。
Osteosarcoma is a common malignant bone tumor in the skeletal system of minors .The five-year survival rate of patients with osteosarcoma is significanty improved by neoadjuvant chemotherapy combined with surgery.However,its mortality and morbidity rates remain quite high .With the development of molecular bi-ology and genetics ,gene therapy provides a new hope for patients with osteosarcoma .Researchers at home and a-broad have actively explored effective therapeutic targets .In this paper ,new progress in the study of gene -targe-ted therapy for osteosarcoma is reviewed .