实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
JOURNAL OF PRACTICAL ONCOLOGY
2014年
4期
360-363
,共4页
马瑞金(综述)%杨宇(审校)
馬瑞金(綜述)%楊宇(審校)
마서금(종술)%양우(심교)
PI3K/AKT/mTOR%Her-2%乳腺肿瘤%靶向治疗
PI3K/AKT/mTOR%Her-2%乳腺腫瘤%靶嚮治療
PI3K/AKT/mTOR%Her-2%유선종류%파향치료
PI3K/AKT/mTOR pathway%Her-2%Breast neoplasms%Targeted therapy
Her-2靶向治疗是Her-2过表达乳腺癌治疗的重要组成部分，但Her-2靶向治疗的耐药严重影响了乳腺癌的治疗。研究证实乳腺癌Her-2靶向治疗出现耐药的过程中有PI3K/AKT/mTOR信号通路的激活，因此对PI3K/AKT/mTOR信号通路及以PI3K/AKT/mTOR信号通路为靶点的药物研究对乳腺癌治疗具有重要意义。
Her-2靶嚮治療是Her-2過錶達乳腺癌治療的重要組成部分，但Her-2靶嚮治療的耐藥嚴重影響瞭乳腺癌的治療。研究證實乳腺癌Her-2靶嚮治療齣現耐藥的過程中有PI3K/AKT/mTOR信號通路的激活，因此對PI3K/AKT/mTOR信號通路及以PI3K/AKT/mTOR信號通路為靶點的藥物研究對乳腺癌治療具有重要意義。
Her-2파향치료시Her-2과표체유선암치료적중요조성부분，단Her-2파향치료적내약엄중영향료유선암적치료。연구증실유선암Her-2파향치료출현내약적과정중유PI3K/AKT/mTOR신호통로적격활，인차대PI3K/AKT/mTOR신호통로급이PI3K/AKT/mTOR신호통로위파점적약물연구대유선암치료구유중요의의。
Her-2 targeting therapy is an important part of the treatment for breast cancer with Her -2 overexpression.However,the therapeutic effectiveness is largely influenced by Her -2 resistance.Previous studies have confirmed that PI3K/AKT/mTOR signaling pathway is activated during the process of drug resistance to Her-2-targeting therapy.Therefore,investigating the PI3K/AKT/mTOR signaling pathway and drugs -targeted pathway are important for the treatment of breast cancer .
