CAJ | 학술논문

目的：甲状腺透明变梁状肿瘤（ HTT）与甲状腺乳头状癌（ TPC）有相似的形态学特征，通过免疫组织化学的方法来对HTT与TPC进行鉴别。方法通过免疫组织化学的方法，检测13例甲状腺透明变梁状肿瘤和20例甲状腺乳头状癌3个指标（CK19，HBME-1，MIB-1）的表达情况。结果在HTT中，CK19：3/13例出现局灶阳性；HBME-1：13例均为阴性；MIB-1：10/13例为细胞核表达。在TPC中， CK19：20例均为阳性表达；HBME-1：19/20阳性表达；MIB-1：20例均呈细胞核表达，CK19和HBME-1联合检测对于鉴别诊断HTT的灵敏度和特异度分别为90．0％和69．2％。结论本研究对于HTT与TPC的鉴别诊断有很大帮助，CK19、HBME-1二项指标联合检测能够很好的鉴别HTT与TPC。
목적：갑상선투명변량상종류（ HTT）여갑상선유두상암（ TPC）유상사적형태학특정，통과면역조직화학적방법래대HTT여TPC진행감별。방법통과면역조직화학적방법，검측13례갑상선투명변량상종류화20례갑상선유두상암3개지표（CK19，HBME-1，MIB-1）적표체정황。결과재HTT중，CK19：3/13례출현국조양성；HBME-1：13례균위음성；MIB-1：10/13례위세포핵표체。재TPC중， CK19：20례균위양성표체；HBME-1：19/20양성표체；MIB-1：20례균정세포핵표체，CK19화HBME-1연합검측대우감별진단HTT적령민도화특이도분별위90．0％화69．2％。결론본연구대우HTT여TPC적감별진단유흔대방조，CK19、HBME-1이항지표연합검측능구흔호적감별HTT여TPC。
Objective Hyalinizing trabecular tumor ( HTT) is often mistaken as thyroid papillary carcino-ma( TPC) ,which shares some morphological features with TPC .The aim of this study is to investigate HTT and TPC with immunohistochemical methods .Methods we detected the expression of the three Immunohistochemical index((CK19,HBME-1,MIB-1)in thirteen cases HTT and twenty cases TPC.Results In HTT samples, CK19:three of the thirteen were positive and focal positivity (1+);HBME-1:None of the thirteen samples was stained.MIB-1:ten in thirteen cases were stained in nucleus .In TPC samples,CK19:all of the twenty samples were intensely stained;HBME-1:nineteen of twenty samples were intensely stained;MIB-1:all of the twenty samples were stained in nucleus .The sensitivity and specific degrees of CK 19 and HBME-1 combination to diag-nosis HTT and TPC were 90.0%and 69.2%.Conclusion Our research could provide potent aid to differential diagnosis of HTT and TPC .The combination of CK19 and HBME-1 are adequate to identify HTT and TPC .