基因组蛋白质组与生物信息学报（英文版）
基因組蛋白質組與生物信息學報（英文版）
기인조단백질조여생물신식학보（영문판）
GENOMICS、PROTEOMICS & BIOINFORMATICS
2014年
4期
178-186
,共9页
Systems biology%Network analysis%Pathway analysis%Network modules%Cytoscape%Budd-Chiari syndrome
The characterization of the interacting behaviors of complex biological systems is a pri-mary objective in protein-protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected pro-tein-protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in dis-eases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.
