CAJ | 학술논문

目的：评价高压氧联合多奈哌齐治疗血管性痴呆的疗效及安全性。方法70例血管性痴呆患者随机分成观察组和对照组各35例。两组均使用多奈哌齐治疗1次/日，观察组在上述治疗的基础上联合高压氧治疗，每日1次，治疗前及治疗8周后应用简易智力状态检查量表（ MMSE）和Barthel指数评分评定疗效。结果观察组总有效率82．9％，对照组总有效率62．8％，两组比较有统计学差异（χ2＝3．540，P＜0．05）。治疗后患者MMSE评分及Bar-thel指数评分较前明显增加，观察组增加更明显（均P＜0．05）。结论高压氧联合多奈哌齐治疗血管性痴呆可明显改善患者智能障碍和生活能力，安全性好，优于单用多奈哌齐。
목적：평개고압양연합다내고제치료혈관성치태적료효급안전성。방법70례혈관성치태환자수궤분성관찰조화대조조각35례。량조균사용다내고제치료1차/일，관찰조재상술치료적기출상연합고압양치료，매일1차，치료전급치료8주후응용간역지력상태검사량표（ MMSE）화Barthel지수평분평정료효。결과관찰조총유효솔82．9％，대조조총유효솔62．8％，량조비교유통계학차이（χ2＝3．540，P＜0．05）。치료후환자MMSE평분급Bar-thel지수평분교전명현증가，관찰조증가경명현（균P＜0．05）。결론고압양연합다내고제치료혈관성치태가명현개선환자지능장애화생활능력，안전성호，우우단용다내고제。
Objective To evaluate the safety and efficacy of hyperbaric oxygen combined with donepezil in the treatment of vasculardementia.Method 70patientswithvasculardementiawererandomlydividedintotreatmentgroupandcontrol group 35 cases each.The two groups were the use of donepezil in the treatment of 1 time /day, the treatment group based on the treatment of combined with use of hyperbaric oxygen in the treatment of 1 time /day.Before and 8 weeks after treatment application scale simple mental state examination ( MMSE) and Barthel index score evaluation of curative effect . Results Treatment group total effectiveness 82.9%, control group total effective rate 62.8%, two groups are statistically significant (P<0.05).After treatment, MMSE score and Barthel index scores were significantly increased , The treatment group increased significantly, with statistically significant difference compared with the control group (P <0.05). Conclusion hyperbaric oxygen combined with donepezil in the treatment of patients with vascular dementia could obviously improve intelligence disorder and living ability , good security , better than use donepezil .