CAJ | 학술논문

目的：探讨腮腺淋巴上皮癌（ LEC）的临床病理特点、免疫组化表型及鉴别诊断。方法收集11例腮腺LEC临床病理资料，进行形态学、免疫组化及原位杂交检测，并复习相关文献。结果腮腺LEC光镜下肿瘤细胞均呈浸润性生长，排列成片状、岛状和条索状；肿瘤细胞边界不清楚，嗜酸性胞质淡染，泡状核呈椭圆形，染色质空，核仁明显；间质为成熟淋巴细胞和浆细胞，常伴有反应性淋巴滤泡增生。5例伴有颈部淋巴结转移，2例伴有神经纤维侵犯。免疫组化检测肿瘤细胞CK、EMA、CK5/6、P63抗体阳性，Vimentin、LCA、CD56抗体阴性；原位杂交检测EBER 10例阳性，1例阴性。结论腮腺LEC是腮腺未分化癌的少见亚型，肿瘤组织由恶性上皮岛和淋巴样组织构成，EBER检测有助于诊断。
목적：탐토시선림파상피암（ LEC）적림상병리특점、면역조화표형급감별진단。방법수집11례시선LEC림상병리자료，진행형태학、면역조화급원위잡교검측，병복습상관문헌。결과시선LEC광경하종류세포균정침윤성생장，배렬성편상、도상화조색상；종류세포변계불청초，기산성포질담염，포상핵정타원형，염색질공，핵인명현；간질위성숙림파세포화장세포，상반유반응성림파려포증생。5례반유경부림파결전이，2례반유신경섬유침범。면역조화검측종류세포CK、EMA、CK5/6、P63항체양성，Vimentin、LCA、CD56항체음성；원위잡교검측EBER 10례양성，1례음성。결론시선LEC시시선미분화암적소견아형，종류조직유악성상피도화림파양조직구성，EBER검측유조우진단。
Objective To study the clinicopathologic characteristics , immunophenotype and differential diagnosis of primary lymphoepithelial carcinoma ( LEC) in the parotid glands .Methods The pathologic features of 11 parotid LEC pa-tients were collected to adopt the immunohistochemical and situ hybridization (ISH) staining test.Results LEC tumor cell present a parotid swelling feature , with sheets , islands and cords array .The tumor cells possess indistinct cell borders , lightly eosinophilic cytoplasm , oval vesicular nulei with open chromatin and conspicuous nuclei .The tumor is infiltrated by lymphocytes and plasma cells , with some accompanied by reactive lymphoid follicles .Metastases to the cervical lymph nodes were found in 5 patients and perineural invasion were found in 2 patients.CK, EMA, P63 and CK5/6 were both pos-itive and Vimentin, LCA,CD56, S-100 were negative in all 11 cases.The EBER was found positive in 10 cases by method of ISH.Conclusion LEC is a rare subtype of undiferentiated carcinoma in the parotid glands .The tumor tissue of LED was composed by malignant epithelial island and lymphoid stroma .LEC test is helpful for pathologic diagnosis of LEC .