CAJ | 학술논문

巨核系造血功能障碍是导致急性放射病患者出血致死亡的主要原因之一。血小板生成素（thrombopoietin，TPO）是巨核系造血的主要刺激因子，可促进照射后巨核系造血功能恢复，升高外周血小板数。在照射后早期应用TPO对急性放射病出血并发症的防治起到关键的作用。研究表明，TPO可能具有更强促进造血恢复的作用，本文就TPO治疗急性放射病的研究进展进行综述。
거핵계조혈공능장애시도치급성방사병환자출혈치사망적주요원인지일。혈소판생성소（thrombopoietin，TPO）시거핵계조혈적주요자격인자，가촉진조사후거핵계조혈공능회복，승고외주혈소판수。재조사후조기응용TPO대급성방사병출혈병발증적방치기도관건적작용。연구표명，TPO가능구유경강촉진조혈회복적작용，본문취TPO치료급성방사병적연구진전진행종술。
Megakaryocytic hematopoietic disorders is one of the leading causes of death in patients with acute radiation sickness bleeding. Thrombopoietin (TPO),the main stimulation factor of megakaryocytopoiesis, can promote megakaryocytic hematopoietic recovery after radiation injury and increase peripheral platelet count. Early application of TPO after irradiation can play a key role in prevention and treatment of bleeding complications of acute radiation sickness. Studies have shown that TPO may have a stronger role in promoting hematopoiesis. In this paper, a brief overview of new progress on the TPO and acute radiation sickness is summarized.