CAJ | 학술논문

硫酸乙酰肝素（HS）和肝素（HP）是由重复的二糖单位组成的高度硫酸化的结构多样性的多糖链， HS通过与蛋白质的相互作用参与了许多相关生物学功能和病理过程的调控，并在其中扮演了重要作用。 HS也在抗病毒方面显示出了潜在药用价值。作为HS的特殊结构形式的HP已在临床上被广泛用作抗凝药物使用，并在抗癌、抗炎方面显示出了药用应用前景。本文针对HS/HP在抗凝、抗癌、抗炎和抗病毒方面的药用价值研究进展进行综述。
류산을선간소（HS）화간소（HP）시유중복적이당단위조성적고도류산화적결구다양성적다당련， HS통과여단백질적상호작용삼여료허다상관생물학공능화병리과정적조공，병재기중분연료중요작용。 HS야재항병독방면현시출료잠재약용개치。작위HS적특수결구형식적HP이재림상상피엄범용작항응약물사용，병재항암、항염방면현시출료약용응용전경。본문침대HS/HP재항응、항암、항염화항병독방면적약용개치연구진전진행종술。
Heparan sulfate (HS) and heparin (HP) are highly sulfated and heterogeneous polysaccharides composed of repeating disaccharide units. HS takes part in regulation of many related biological functions through its interaction with proteins and plays an important role in them. HS is also shown to have promising perspectives as a potential antivirus agent. As a special structure type of HS, HP is also widely used as the clinical anticoagulant drug and demonstrated to be a promising candidate for anticancer and anti-inflammatory drugs. Progress of the research in the areas of anticoagulant, anticancer, anti-inflammatory and antivirus activity of HS/HP and their chemoenzymatic synthesis is summarized in this review.