CAJ | 학술논문

宫内节育器（intrauterine device，IUD）是目前广泛使用的长效避孕方法之一。目前中国已普遍使用含铜IUD，但是放置含铜IUD的妇女常出现一些不良反应，如月经过多、不规则出血、白带异常和疼痛等，其中以子宫异常出血发生率最高，严重影响了患者对含铜IUD的认可和接受性，这也是一直困扰临床的一个不可忽视的问题。目前已证明人子宫内膜存在多种血管生成因子。其中血管内皮生长因子（VEGF）是子宫内膜血管形成的重要调控因子，并受多种因子调控。对VEGF及相关因子与含铜IUD致子宫异常出血关系的多项研究，为含铜IUD不良反应的靶向治疗开辟了新的前景。
궁내절육기（intrauterine device，IUD）시목전엄범사용적장효피잉방법지일。목전중국이보편사용함동IUD，단시방치함동IUD적부녀상출현일사불량반응，여월경과다、불규칙출혈、백대이상화동통등，기중이자궁이상출혈발생솔최고，엄중영향료환자대함동IUD적인가화접수성，저야시일직곤우림상적일개불가홀시적문제。목전이증명인자궁내막존재다충혈관생성인자。기중혈관내피생장인자（VEGF）시자궁내막혈관형성적중요조공인자，병수다충인자조공。대VEGF급상관인자여함동IUD치자궁이상출혈관계적다항연구，위함동IUD불량반응적파향치료개벽료신적전경。
Intrauterine device(IUD) is one of the widely used long-acting contraceptive methods. At present,our country has the widespread use of copper containing IUD ,but the placement of IUD women often have some adverse reactions ,such as menorrhagia,irregular bleeding,abnormal vaginal discharge,pain,especially with the highest incidence of abnormal uterine bleeding. Patients with a serious impact on recognition of copper containing IUD and acceptance ,which has been plagued by a problem that can not be ignored in clinic. At present it has been proved that human endometrium contains a variety of angiogenesis factor. Vascular endothelial growth factor (VEGF) is an important regulator of endometrial vessels formed,and affected by many factors. A number of research on the relationship between VEGF and related factors and the copper IUD induced abnormal uterine bleeding ,the copper containing IUD side reactions of targeted therapy has opened up a new prospect.