CAJ | 학술논문

目的：系统评价单纯针灸相关疗法治疗原发性痛经（primary dysmenorrhea，PD）的效果。方法：计算机检索PubMed、Web of Science（SCI）、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、中文期刊全文数据库（VIP）及万方数字化期刊全文数据库（WANFANG DATA）等数据库中关于单纯针灸相关疗法治疗PD的随机对照试验（RCTs），检索时限均为从建库至2012年12月。依据纳入与排除标准独立检索上述数据库、筛选文献、提取资料及文献质量评价后，利用Cochrane协作网提供的RevMan 5.2.4软件进行Meta 分析。结果：最终纳入20个RCTs，共2134例患者。 Meta分析结果显示：①单纯针灸相关疗法治疗组患者的总疗效优于对照疗法组，差异有统计学意义（RR=1.19，95%CI：1.14～1.24，P＜0.000）和（RR=1.15，95%CI：1.10～1.21，P=0.03）。②在痛经症状方面，单纯针灸相关疗法治疗组患者症状缓解程度明显优于对照疗法组，差异有统计学意义（MD=3.20，95%CI：2.36～3.04，P＜0.000）和（MD=2.09，95%CI：0.16～4.02，P=0.03）。③对于降低外周血前列腺素F2α（prostaglandins F2α，PGF2α），两组差异无统计学意义（MD=0.13，95%CI：-0.13～0.39，P=0.32）。结论：单纯针灸相关疗法能有效地缓解PD患者的症状，且在总有效率方面也具有显著的优势。因本次纳入研究的数量和质量存在一定局限，上述结论尚待开展大样本、多中心研究加以验证。
목적：계통평개단순침구상관요법치료원발성통경（primary dysmenorrhea，PD）적효과。방법：계산궤검색PubMed、Web of Science（SCI）、중국생물의학문헌수거고（CBM）、중국기간전문수거고（CNKI）、중문기간전문수거고（VIP）급만방수자화기간전문수거고（WANFANG DATA）등수거고중관우단순침구상관요법치료PD적수궤대조시험（RCTs），검색시한균위종건고지2012년12월。의거납입여배제표준독립검색상술수거고、사선문헌、제취자료급문헌질량평개후，이용Cochrane협작망제공적RevMan 5.2.4연건진행Meta 분석。결과：최종납입20개RCTs，공2134례환자。 Meta분석결과현시：①단순침구상관요법치료조환자적총료효우우대조요법조，차이유통계학의의（RR=1.19，95%CI：1.14～1.24，P＜0.000）화（RR=1.15，95%CI：1.10～1.21，P=0.03）。②재통경증상방면，단순침구상관요법치료조환자증상완해정도명현우우대조요법조，차이유통계학의의（MD=3.20，95%CI：2.36～3.04，P＜0.000）화（MD=2.09，95%CI：0.16～4.02，P=0.03）。③대우강저외주혈전렬선소F2α（prostaglandins F2α，PGF2α），량조차이무통계학의의（MD=0.13，95%CI：-0.13～0.39，P=0.32）。결론：단순침구상관요법능유효지완해PD환자적증상，차재총유효솔방면야구유현저적우세。인본차납입연구적수량화질량존재일정국한，상술결론상대개전대양본、다중심연구가이험증。
Objective: To systematically review the effectiveness of associated simple acupuncture therapy in the treatment of primary dysmenorrhea (PD). Methods:Databases such as PubMed,Web of Science (SCI),CBM,CNKI,VIP and WANFANG DATA were electronically searched to collect the randomized controlled trials (RCTs)(up to December 2012),and the relevant references of the included articles were also manually searched. According to the inclusion and exclusion criteria , literature was screened,data were extracted and methodological quality of the included studies was assessed. Then Meta analyses were performed by using RevMan 5.2 software. Results:A total of 20 RCTs involving 2 134 participants were included. Results of Meta analyses showed that: ①total efficiency of associated simple acupuncture therapy was better than that of control method , with statistically significant differences [RR=1.19,95%CI(1.14,1.24),P<0.000] and [RR=1.15,95%CI(1.10,1.21),P=0.03].②Associated simple acupuncture therapy was better than control method in releasing degree of serious symptoms of PD ,with statistically significant differences [MD=3.20,95%CI (2.36,3.04),P<0.000] and [MD=2.09,95%CI (0.16,4.02),P=0.03].③There was no statistical difference in reducing level of the peripheral blood prostaglandin F 2αbetween the two groups [MD=0.13,95%CI(-0.13,0.39),P=0.32]. Conclusions:Associated simple acupuncture therapy can significantly relieve pain in patients with PD and overall efficiency. Due to limitations on the quantity and quality of included studies ,this conclusion has yet to be carried out in large, multicenter study to verify.