CAJ | 학술논문

微小RNA（microRNA，miRNA）是一种通过翻译后、转录和转录后水平调控mRNA的单链非编码RNA，可作为抑癌基因和癌基因参与肿瘤的发生、发展及侵袭。近期研究发现一些miRNA与子宫内膜癌（EC）的癌基因表达有关，例如miRNA-200家族，miRNA-205，miR-129-2，miR-203，miR-302，miR-194，miR-30c，miR-204，miR-34，miR-125， miRNA-152，miRNA-503等，均已证实与EC的癌基因具有相关性。随着对miRNAs研究的不断深入，miRNA有望成为EC的有效新靶点之一应用于临床。现综述近年与EC相关的miRNA研究进展。
미소RNA（microRNA，miRNA）시일충통과번역후、전록화전록후수평조공mRNA적단련비편마RNA，가작위억암기인화암기인삼여종류적발생、발전급침습。근기연구발현일사miRNA여자궁내막암（EC）적암기인표체유관，례여miRNA-200가족，miRNA-205，miR-129-2，miR-203，miR-302，miR-194，miR-30c，miR-204，miR-34，miR-125， miRNA-152，miRNA-503등，균이증실여EC적암기인구유상관성。수착대miRNAs연구적불단심입，miRNA유망성위EC적유효신파점지일응용우림상。현종술근년여EC상관적miRNA연구진전。
microRNAs (miRNAs) are non-coding RNAs that can regulate mRNA in the level of post-translational modification,transcription and post-transcription. And they are associated with growth,development and invading of tumors as oncogenic miRNAs and tumor suppressor miRNAs. Relationships of miRNAs with endometrial cancer (EC) have recently emerged. For instance,miRNA-200 family,miRNA-205,miR-129-2,miR-203,miR-302,miR-194,miR-30c,miR-204, miR-34,miR-125,miRNA-152,miRNA-503,etc. With the deeper research,miRNAs may be used in clinical applications as one of new targets. In this article ,there is an overview about the recent research of miRNAs and EC.