国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
2014年
4期
395-400
,共6页
受体,G蛋白偶联%癌%子宫内膜肿瘤%卵巢肿瘤%成纤维细胞
受體,G蛋白偶聯%癌%子宮內膜腫瘤%卵巢腫瘤%成纖維細胞
수체,G단백우련%암%자궁내막종류%란소종류%성섬유세포
Receptors,G-protein-coupled%Carcinoma%Endometrial neoplasms%Ovarian neoplasms%Fibroblasts
子宫内膜癌和卵巢癌均是女性生殖系统的恶性肿瘤,发病率呈逐年升高趋势,但发病机制尚未明了。近年发现,雌激素可介导新型G蛋白偶联受体30(GPR30)通过快速非基因转录途径调控肿瘤细胞增殖与凋亡,参与肿瘤发生发展。肿瘤相关成纤维细胞在肿瘤发展中的作用也不断受到重视。综述GPR30在子宫内膜癌及卵巢癌中的表达,分析探讨GPR30在妇科肿瘤发病机制中细胞增殖、凋亡等相关调控作用,以期为子宫内膜癌及卵巢癌的临床治疗提供新的靶点。
子宮內膜癌和卵巢癌均是女性生殖繫統的噁性腫瘤,髮病率呈逐年升高趨勢,但髮病機製尚未明瞭。近年髮現,雌激素可介導新型G蛋白偶聯受體30(GPR30)通過快速非基因轉錄途徑調控腫瘤細胞增殖與凋亡,參與腫瘤髮生髮展。腫瘤相關成纖維細胞在腫瘤髮展中的作用也不斷受到重視。綜述GPR30在子宮內膜癌及卵巢癌中的錶達,分析探討GPR30在婦科腫瘤髮病機製中細胞增殖、凋亡等相關調控作用,以期為子宮內膜癌及卵巢癌的臨床治療提供新的靶點。
자궁내막암화란소암균시녀성생식계통적악성종류,발병솔정축년승고추세,단발병궤제상미명료。근년발현,자격소가개도신형G단백우련수체30(GPR30)통과쾌속비기인전록도경조공종류세포증식여조망,삼여종류발생발전。종류상관성섬유세포재종류발전중적작용야불단수도중시。종술GPR30재자궁내막암급란소암중적표체,분석탐토GPR30재부과종류발병궤제중세포증식、조망등상관조공작용,이기위자궁내막암급란소암적림상치료제공신적파점。
Endometrial and ovarian carcinomas are malignant neoplasms in the female reproductive system. Estrogen has been proved as an epidemic factor throughout gynecological carcinoma. Recently, it has been found that G-protein-coupled receptor 30 (GPR30) mediates cell proliferation and survival through nongenomic effects in hypo-exposure of estrogen. Moreover, the role of tumor associated fibroblasts in carcinoma has frequently been taken into account. We review and reveal the role of GPR30 in the regulation of endometrial and ovarian carcinomas in order to provide new molecular target therapy.