CAJ | 학술논문

目的：探讨整合素α5β1、P-选择素表达与宫颈鳞癌生物学行为的关系。方法：采用免疫组化SP法检测60例宫颈鳞癌组织和40例宫颈正常组织整合素α5β1和P-选择素的表达情况，分析二者与宫颈鳞癌生物学行为的关系及二者的相关性。结果：整合素α5β1、P-选择素在宫颈鳞癌组织中的阳性表达率分别为65.0%、71.7%，均高于宫颈正常组织(P ＜0.05)。整合素α5β1、P-选择素的表达与宫颈鳞癌的分化程度、pTNM分期、淋巴结转移及浸润深度有关(P ＜0.05)。宫颈鳞癌中整合素α5β1和P-选择素的表达呈正相关关系(P ＜0.05)。结论：整合素α5β1、P-选择素与宫颈鳞癌的生长、浸润与转移密切相关，联合检测整合素α5β1和P-选择素可作为评估宫颈鳞癌的恶性程度和预后的指标。
목적：탐토정합소α5β1、P-선택소표체여궁경린암생물학행위적관계。방법：채용면역조화SP법검측60례궁경린암조직화40례궁경정상조직정합소α5β1화P-선택소적표체정황，분석이자여궁경린암생물학행위적관계급이자적상관성。결과：정합소α5β1、P-선택소재궁경린암조직중적양성표체솔분별위65.0%、71.7%，균고우궁경정상조직(P ＜0.05)。정합소α5β1、P-선택소적표체여궁경린암적분화정도、pTNM분기、림파결전이급침윤심도유관(P ＜0.05)。궁경린암중정합소α5β1화P-선택소적표체정정상관관계(P ＜0.05)。결론：정합소α5β1、P-선택소여궁경린암적생장、침윤여전이밀절상관，연합검측정합소α5β1화P-선택소가작위평고궁경린암적악성정도화예후적지표。
Objective:To investigate the relationship between integrin α5β1, P-selectin expression and biological behavior of cervical squamous carcinoma. Methods:SP immunohistochemical staining was used to detect the expression of integrin α5β1 and P-selectin in 60 cases cervical squamous carcinoma and 40 cases normal cervical tissue; and analyzed the correlation of integrin α5β1 and P-selectin in cervical squamous carcinoma, as well as the relationship between them and biological behavior of cervical squamous carcinoma.Results:The positive expression rate of integrin α5β1 and P-selectin in cervical squamous carcinoma was 65.0% and 71.7%, which were all obviously higher than that of normal cervical tissue (P< 0.05).The expression of integrin α5β1 and P-selectin in cervical squamous carcinoma were related to differentiated degree, pTNM stage, lymph node metastasis and infiltration depth (P< 0.05). In cervical squamous carcinoma, the expression of integrin α5β1 was positively correlated to expression of P-selectin (P< 0.05). Conclusions: Integrin α5β1 and P-selectin have close relation with growth, infiltration and metastasis of cervical squamous carcinoma. Joint detection of integrin α5β1 and P-selectincanbeactedas indextoevaluatethemalignant degree and prognosis ofcervical squamous carcinoma.