中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
7期
419-423
,共5页
吕建宝%张向阳%李娟%杨甫德
呂建寶%張嚮暘%李娟%楊甫德
려건보%장향양%리연%양보덕
精神分裂症%氯氮平%QTc间期延长
精神分裂癥%氯氮平%QTc間期延長
정신분렬증%록담평%QTc간기연장
schizophrenia%clozapine%QTc interval prolongation
目的：调查精神分裂症患者在氯氮平治疗期间心电图校正QT间期（corrected QT interval，QTc）的变化及其相关因素。方法收集使用氯氮平治疗的210例精神分裂症患者，检测心肌酶等生化指标，检查心电图，按Bazett’s公式计算QTc间期，并以桡动脉搏动次数作为心率。结果 QTc间期延长发生率15.24%，女性QTc间期延长发生率高于男性（29.23%vs.8.98%），差异有统计学意义（P<0.001）。女性QTc间期比男性长[（427.30±24.33）ms vs.（410.39±25.80）ms]，差异有统计学意义（P<0.001）。QTc间期与年龄（r=0.203，P=0.003）、心率（r=0.326，P<0.001）呈正相关，与氯氮平剂量、治疗时间无统计学相关（均P>0.05）。多因素线性回归分析示，心率与QTc间期有关联（β=0.719，标准化β=0.691，P=0.027）。结论精神分裂症患者在氯氮平治疗期间QTc间期延长发生率高，心率快可能是其危险因素。
目的：調查精神分裂癥患者在氯氮平治療期間心電圖校正QT間期（corrected QT interval，QTc）的變化及其相關因素。方法收集使用氯氮平治療的210例精神分裂癥患者，檢測心肌酶等生化指標，檢查心電圖，按Bazett’s公式計算QTc間期，併以橈動脈搏動次數作為心率。結果 QTc間期延長髮生率15.24%，女性QTc間期延長髮生率高于男性（29.23%vs.8.98%），差異有統計學意義（P<0.001）。女性QTc間期比男性長[（427.30±24.33）ms vs.（410.39±25.80）ms]，差異有統計學意義（P<0.001）。QTc間期與年齡（r=0.203，P=0.003）、心率（r=0.326，P<0.001）呈正相關，與氯氮平劑量、治療時間無統計學相關（均P>0.05）。多因素線性迴歸分析示，心率與QTc間期有關聯（β=0.719，標準化β=0.691，P=0.027）。結論精神分裂癥患者在氯氮平治療期間QTc間期延長髮生率高，心率快可能是其危險因素。
목적：조사정신분렬증환자재록담평치료기간심전도교정QT간기（corrected QT interval，QTc）적변화급기상관인소。방법수집사용록담평치료적210례정신분렬증환자，검측심기매등생화지표，검사심전도，안Bazett’s공식계산QTc간기，병이뇨동맥박동차수작위심솔。결과 QTc간기연장발생솔15.24%，녀성QTc간기연장발생솔고우남성（29.23%vs.8.98%），차이유통계학의의（P<0.001）。녀성QTc간기비남성장[（427.30±24.33）ms vs.（410.39±25.80）ms]，차이유통계학의의（P<0.001）。QTc간기여년령（r=0.203，P=0.003）、심솔（r=0.326，P<0.001）정정상관，여록담평제량、치료시간무통계학상관（균P>0.05）。다인소선성회귀분석시，심솔여QTc간기유관련（β=0.719，표준화β=0.691，P=0.027）。결론정신분렬증환자재록담평치료기간QTc간기연장발생솔고，심솔쾌가능시기위험인소。
Objective To investigate risk factors of corrected QT (QTc) interval prolongation in schizophrenia pa-tients treated with clozapine. Methods Two hundred and ten schizophrenia patients treated with clozapine were included in the study. Measurement of myocardial enzymes and electrocardiography were performed to determine QTc interval. QTc interval was calculated according to Bazett’s formula. Results QTc prolongation prevalence rate was 15.24%, The QTc prolongation prevalence rate was higher in female than in male (29.23%vs. 8.98%, P<0.001). The mean QTc inter-val was longer in female than in male [(427.30 ± 24.33)ms vs. (410.39 ± 25.80)ms, P<0.001]. The QTc interval showed weak positive correlation with age (r=0.203, P=0.003) and heart rate (r=0.326, P<0.001). There was no correlation be-tween QTc interval and clozapine dosage or therapy course (P>0.05). Multi-factors linear regression analysis showed that heart rate was related with QTc interval (β=0.719, standardizedβ=0.691, P=0.027). Conclusions QTc interval prolonga-tion prevalence rate is high in patients treated with clozapine. And increased heart rate might be risk factor of QTc inter-val prolongation.
