中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
8期
1251-1252
,共2页
幽门螺杆菌%质子泵抑制剂%埃索美拉唑%奥美拉唑
幽門螺桿菌%質子泵抑製劑%埃索美拉唑%奧美拉唑
유문라간균%질자빙억제제%애색미랍서%오미랍서
Helicobacter pylori%Proton pump inhibitor%Esomeprazole%Omeprazole
目的：系统评价奥美拉唑和埃索美拉唑治疗幽门螺杆菌感染的疗效差异。方法：选择报道比较埃索美拉唑和奥美拉唑的临床随机试验的研究。在PubMed和Cochranelibrary数据库中通过电子和手工搜索文献；计算了成功治疗H.pylori感染的百分比，然后对每项研究的比值比（odds ratio）进行Meta分析。结果：Meta分析（14项研究，3555患者）显示埃索美拉唑和奥美拉唑根除幽门螺杆菌感染的效率分别为80.8%和77.2%，OR值为1.15（95%可信区间为0.95～1.40）。结论：埃索美拉唑和奥美拉唑均能高效根除幽门螺杆菌感染，但两者对幽门螺杆菌的根除效率相当。
目的：繫統評價奧美拉唑和埃索美拉唑治療幽門螺桿菌感染的療效差異。方法：選擇報道比較埃索美拉唑和奧美拉唑的臨床隨機試驗的研究。在PubMed和Cochranelibrary數據庫中通過電子和手工搜索文獻；計算瞭成功治療H.pylori感染的百分比，然後對每項研究的比值比（odds ratio）進行Meta分析。結果：Meta分析（14項研究，3555患者）顯示埃索美拉唑和奧美拉唑根除幽門螺桿菌感染的效率分彆為80.8%和77.2%，OR值為1.15（95%可信區間為0.95～1.40）。結論：埃索美拉唑和奧美拉唑均能高效根除幽門螺桿菌感染，但兩者對幽門螺桿菌的根除效率相噹。
목적：계통평개오미랍서화애색미랍서치료유문라간균감염적료효차이。방법：선택보도비교애색미랍서화오미랍서적림상수궤시험적연구。재PubMed화Cochranelibrary수거고중통과전자화수공수색문헌；계산료성공치료H.pylori감염적백분비，연후대매항연구적비치비（odds ratio）진행Meta분석。결과：Meta분석（14항연구，3555환자）현시애색미랍서화오미랍서근제유문라간균감염적효솔분별위80.8%화77.2%，OR치위1.15（95%가신구간위0.95～1.40）。결론：애색미랍서화오미랍서균능고효근제유문라간균감염，단량자대유문라간균적근제효솔상당。
To conduct a meta-analysis of studies comparing esomeprazole and omeprazole in the treatment of H.pylori infection.Methods:To select studies which are randomised, clinical trials comparing esomeprazole with omeprazole. Electronic and manual bibligraphical searches were conducted in PubMed and Cochranelibrary. The percentages of treatment success of of H.pylori infection were calculated. Meta-analysis was performed the odd ratios (OR) of the individual studies.Results:The meta-analysis (fourteen studies, 3555 patients) exhibited the eradication efficacy of esomeprazole and omeprazole for H.pylori infection is 80.8% and 77.2%, respectively. OR is 1.15 with 95% CI from 0.95 to 1.40.Conclusion:Both esomeprazole and omeprazole also treat H.pylori infection with highly efficacy. However, the efficacy of esomeprazole for eradication of H.pylori is comparable to that of omeprazole.
