中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
8期
82-84
,共3页
胺碘酮%美托洛尔%肥厚型心肌病%恶性室性心律失常
胺碘酮%美託洛爾%肥厚型心肌病%噁性室性心律失常
알전동%미탁락이%비후형심기병%악성실성심률실상
Amiodarone%Metoprolol%Hypertrophic Cardiomyopathy%Malignant ventricular arrhythmia
目的：探讨小剂量胺碘酮联合美托洛尔治疗肥厚型心肌病伴恶性室性心律失常的临床疗效。方法选择肥厚型心肌病伴恶性室性心律失常患者82例，所有患者均给予小剂量胺碘酮联合美托洛尔，治疗3个月后，复查Holter等相关检查以评价临床治疗效果，并观察治疗过程中的不良反应发生情况。结果82例患者中，62例治疗有效，病情缓解，20例治疗无效，治疗有效率为75.61%。治疗前后最长QT间期的变化无显著差异；治疗后最短QT间期显著长于治疗前（P＜0.05）；治疗前的QT离散度为（96±29）ms，显著高于治疗后[（64±17）ms]（P＜0.05）。4例患者治疗期间出现轻微恶心欲呕症状，2例患者出现窦性心动过缓，不良反应发生率为14.63%。结论小剂量胺碘酮联合美托洛尔治疗肥厚型心肌病伴恶性室性心律失常具有较好的临床疗效，可使患者病情稳定，改善其预后，且不良反应少，值得在临床进一步推广应用。
目的：探討小劑量胺碘酮聯閤美託洛爾治療肥厚型心肌病伴噁性室性心律失常的臨床療效。方法選擇肥厚型心肌病伴噁性室性心律失常患者82例，所有患者均給予小劑量胺碘酮聯閤美託洛爾，治療3箇月後，複查Holter等相關檢查以評價臨床治療效果，併觀察治療過程中的不良反應髮生情況。結果82例患者中，62例治療有效，病情緩解，20例治療無效，治療有效率為75.61%。治療前後最長QT間期的變化無顯著差異；治療後最短QT間期顯著長于治療前（P＜0.05）；治療前的QT離散度為（96±29）ms，顯著高于治療後[（64±17）ms]（P＜0.05）。4例患者治療期間齣現輕微噁心欲嘔癥狀，2例患者齣現竇性心動過緩，不良反應髮生率為14.63%。結論小劑量胺碘酮聯閤美託洛爾治療肥厚型心肌病伴噁性室性心律失常具有較好的臨床療效，可使患者病情穩定，改善其預後，且不良反應少，值得在臨床進一步推廣應用。
목적：탐토소제량알전동연합미탁락이치료비후형심기병반악성실성심률실상적림상료효。방법선택비후형심기병반악성실성심률실상환자82례，소유환자균급여소제량알전동연합미탁락이，치료3개월후，복사Holter등상관검사이평개림상치료효과，병관찰치료과정중적불량반응발생정황。결과82례환자중，62례치료유효，병정완해，20례치료무효，치료유효솔위75.61%。치료전후최장QT간기적변화무현저차이；치료후최단QT간기현저장우치료전（P＜0.05）；치료전적QT리산도위（96±29）ms，현저고우치료후[（64±17）ms]（P＜0.05）。4례환자치료기간출현경미악심욕구증상，2례환자출현두성심동과완，불량반응발생솔위14.63%。결론소제량알전동연합미탁락이치료비후형심기병반악성실성심률실상구유교호적림상료효，가사환자병정은정，개선기예후，차불량반응소，치득재림상진일보추엄응용。
Objective To investigate the clinical efficacy of small dose of amiodarone combined with metoprolol in the treatment of hypertrophic cardiomyopathy with malignant ventricular arrhythmia. Method 82 patients with hypertrophic cardiomyopathy with malignant ventricular arrhythmia were selected in our hospital. All patients were given an oral therapy of small dose of amiodarone combined with metoprolol, after 3 months of therapy, the holter related testing was performed to evaluate the therapeutic effect and adverse reaction of therapeutic process. Result After treatment, effective in 62 patients, 20 cases ineffective, the efficiency was 75.61%. The changes of the long QT interval before and after treatment showed no statistical signiifcant;after treatment, the short QT interval was signiifcantly longer than that before treatment;QT dispersion before treatment was (96±29) ms, after treatment, it was (64±17) ms, which was significantly shorter than before treatment. Mild nausea symptoms occurred in 8 patients during the treatment, 4 cases of sinus heartbeat bradycardia, the adverse reaction incidence rate was 14.63%. Conclusion Small dose of amiodarone combined with metoprolol in the treatment of hypertrophic cardiomyopathy with malignant ventricular arrhythmia has better clinical efifcacy, can stabilize the patient's condition, improve the prognosis of the patients, and less adverse reaction, it is worth popularizing in clinic.
