中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
8期
29-31
,共3页
越鞠丸%不同工艺栀子%抗抑郁%小鼠悬尾实验%小鼠强迫游泳实验
越鞠汍%不同工藝梔子%抗抑鬱%小鼠懸尾實驗%小鼠彊迫遊泳實驗
월국환%불동공예치자%항억욱%소서현미실험%소서강박유영실험
Yueju pills%Different processes of Fructus Gardeniae%Antidepressant%Tail suspension test%Forced swimming test
目的：探讨越鞠丸中不同工艺的栀子（生栀子、炒栀子、焦栀子）醇提物的抗抑郁活性。方法采用小鼠悬尾和强迫小鼠游泳实验两种行为绝望法复制小鼠抑郁模型，对越鞠丸中不同工艺的栀子醇提物分别进行抗抑郁活性研究。结果越鞠丸中不同工艺的栀子（生栀子、炒栀子、焦栀子）醇提物均能不同程度地缩短小鼠悬尾不动时间和小鼠强迫游泳不动时间，具有抗抑郁活性；焦栀子可显著缩短小鼠悬尾不动时间和游泳不动时间（P＜0.05）。结论越鞠丸中不同工艺的栀子（生栀子、炒栀子、焦栀子）醇提物均有不同程度的抗抑郁活性，其中抗抑郁活性最高为焦栀子。
目的：探討越鞠汍中不同工藝的梔子（生梔子、炒梔子、焦梔子）醇提物的抗抑鬱活性。方法採用小鼠懸尾和彊迫小鼠遊泳實驗兩種行為絕望法複製小鼠抑鬱模型，對越鞠汍中不同工藝的梔子醇提物分彆進行抗抑鬱活性研究。結果越鞠汍中不同工藝的梔子（生梔子、炒梔子、焦梔子）醇提物均能不同程度地縮短小鼠懸尾不動時間和小鼠彊迫遊泳不動時間，具有抗抑鬱活性；焦梔子可顯著縮短小鼠懸尾不動時間和遊泳不動時間（P＜0.05）。結論越鞠汍中不同工藝的梔子（生梔子、炒梔子、焦梔子）醇提物均有不同程度的抗抑鬱活性，其中抗抑鬱活性最高為焦梔子。
목적：탐토월국환중불동공예적치자（생치자、초치자、초치자）순제물적항억욱활성。방법채용소서현미화강박소서유영실험량충행위절망법복제소서억욱모형，대월국환중불동공예적치자순제물분별진행항억욱활성연구。결과월국환중불동공예적치자（생치자、초치자、초치자）순제물균능불동정도지축단소서현미불동시간화소서강박유영불동시간，구유항억욱활성；초치자가현저축단소서현미불동시간화유영불동시간（P＜0.05）。결론월국환중불동공예적치자（생치자、초치자、초치자）순제물균유불동정도적항억욱활성，기중항억욱활성최고위초치자。
Objective To explore the antidepressant effect of Ethanol extracts of different processes of Fructus Gardeniae (raw gardenia, fried gardenia, baked gardenia) in Yueju pills. Method Two behavioral despair animal models (the tail suspension test and the forced swimming test of mice) were used to respectively study the antidepressant effect of Ethanol extracts of different processes of Fructus Gardeniae in Yueju pills. Result The Ethanol extracts of different processes of (raw gardenia, fried gardenia, baked gardenia) in Yueju pills can in different degrees shorten the duration of tail suspension and forced swimming of mice and had antidepressant effect. Baked gardenia can signiifcantly shorten the duration of tail suspension and forced swimming of mice. Conclusion The Ethanol extracts of different processes of Fructus Gardeniae (raw gardenia, fried gardenia, baked gardenia) in Yueju pills have different degrees of antidepressant effect, among them baked gardenia has the highest antidepressant effect.
