中国感染控制杂志
中國感染控製雜誌
중국감염공제잡지
CHINESE JOURNAL OF INFECTION CONTROL
2014年
8期
482-485
,共4页
陈振华%谭笑%余艳艳%谭云洪
陳振華%譚笑%餘豔豔%譚雲洪
진진화%담소%여염염%담운홍
结核,肺%结核分枝杆菌%细菌%真菌%降钙素原%诊断
結覈,肺%結覈分枝桿菌%細菌%真菌%降鈣素原%診斷
결핵,폐%결핵분지간균%세균%진균%강개소원%진단
pulmonary tuberculosis%Mycobacterium tuberculosis%bacteria%fungus%procalcitonin%diagnosis
目的:探讨血清降钙素原(PCT)对肺结核(PTB)合并肺部感染早期诊断的临床价值。方法收集某院2013年8-12月收治的确诊活动性 PTB 患者的临床资料,依据 PTB 患者合并细菌、真菌感染分为合并细菌感染组(n=104)和合并真菌感染组(n=37),同期该院确诊的活动性 PTB 未合并感染者作为对照组(n =95),比较3组患者血清 PCT 浓度,并进行接受者操作特性(ROC)曲线分析。结果合并细菌和真菌感染组患者 PCT 中位浓度分别是0.44 ng/mL 和0.30 ng/mL,均明显高于未合并感染组的0.16 ng/mL,差异具有统计学意义(Z 值分别为9.49、3.51,均 P <0.001)。合并细菌和真菌感染组 PCT 的 ROC 曲线下面积分别为0.89(0.84~0.93)和0.69(0.61~0.77);临界值分别为0.31 ng/mL、0.27 ng/mL;灵敏度分别为79.81%(70.57%~86.80%)、59.46%(42.19%~74.80%);特异度分别为83.16%(73.79%~89.78%)、73.68%(63.48%~81.95%)。结论血清PCT 对早期诊断肺结核合并肺部细菌感染有一定价值,并且能为临床合理、正确选用抗菌药物提供参考依据。
目的:探討血清降鈣素原(PCT)對肺結覈(PTB)閤併肺部感染早期診斷的臨床價值。方法收集某院2013年8-12月收治的確診活動性 PTB 患者的臨床資料,依據 PTB 患者閤併細菌、真菌感染分為閤併細菌感染組(n=104)和閤併真菌感染組(n=37),同期該院確診的活動性 PTB 未閤併感染者作為對照組(n =95),比較3組患者血清 PCT 濃度,併進行接受者操作特性(ROC)麯線分析。結果閤併細菌和真菌感染組患者 PCT 中位濃度分彆是0.44 ng/mL 和0.30 ng/mL,均明顯高于未閤併感染組的0.16 ng/mL,差異具有統計學意義(Z 值分彆為9.49、3.51,均 P <0.001)。閤併細菌和真菌感染組 PCT 的 ROC 麯線下麵積分彆為0.89(0.84~0.93)和0.69(0.61~0.77);臨界值分彆為0.31 ng/mL、0.27 ng/mL;靈敏度分彆為79.81%(70.57%~86.80%)、59.46%(42.19%~74.80%);特異度分彆為83.16%(73.79%~89.78%)、73.68%(63.48%~81.95%)。結論血清PCT 對早期診斷肺結覈閤併肺部細菌感染有一定價值,併且能為臨床閤理、正確選用抗菌藥物提供參攷依據。
목적:탐토혈청강개소원(PCT)대폐결핵(PTB)합병폐부감염조기진단적림상개치。방법수집모원2013년8-12월수치적학진활동성 PTB 환자적림상자료,의거 PTB 환자합병세균、진균감염분위합병세균감염조(n=104)화합병진균감염조(n=37),동기해원학진적활동성 PTB 미합병감염자작위대조조(n =95),비교3조환자혈청 PCT 농도,병진행접수자조작특성(ROC)곡선분석。결과합병세균화진균감염조환자 PCT 중위농도분별시0.44 ng/mL 화0.30 ng/mL,균명현고우미합병감염조적0.16 ng/mL,차이구유통계학의의(Z 치분별위9.49、3.51,균 P <0.001)。합병세균화진균감염조 PCT 적 ROC 곡선하면적분별위0.89(0.84~0.93)화0.69(0.61~0.77);림계치분별위0.31 ng/mL、0.27 ng/mL;령민도분별위79.81%(70.57%~86.80%)、59.46%(42.19%~74.80%);특이도분별위83.16%(73.79%~89.78%)、73.68%(63.48%~81.95%)。결론혈청PCT 대조기진단폐결핵합병폐부세균감염유일정개치,병차능위림상합리、정학선용항균약물제공삼고의거。
Objective To evaluate the clinical significance of serum procalcitonin (PCT)in early diagnosis of pul-monary tuberculosis (PTB)complicated with pulmonary infection.Methods Clinical data of active PTB patients admitted to a hospital between August and December 2013 were collected,patients were divided into bacterial infec-tion group(n=104),fungal infection group(n=37)and control group (n=95)according to whether patients were associated with bacterial infection,fungal infection,and without infection,serum PCT concentrations in three groups were compared,receiver operating characteristic (ROC)curve analysis was conducted.Results The median PCT concentrations in bacterial infection and fungal infection group was 0.44ng/mL and 0.30ng/mL respectively, which was significantly higher than 0.16ng/mL of control group(Z =9.49,3.51 respectively,both P <0.001 ).The area under curve (AUC)was 0.89(0.84-0.93)and 0.69(0.61 -0.77)respectively;cut-off point was 0.31 ng/mL and 0.27 ng/mL respectively;sensitivity was 79.81%(70.57%-86.80%)and 59.46%(42.19%-74.80%)respectively;specificity was 83.16%(73.79%-89.78%)and 73.68%(63.48%-81.95%)respectively.Conclusion PCT level is a valuable predictor for early diagnosis of PTB complicated with pulmonary infection,and can provide reference for the rational use of antimicrobial agents.