中国介入心脏病学杂志
中國介入心髒病學雜誌
중국개입심장병학잡지
CHINESE JOURNAL OF INTERVENTIONAL CARDIOLOGY
2014年
8期
488-491
,共4页
李绍生%邓捷%赵昕%史雅娜%王效增
李紹生%鄧捷%趙昕%史雅娜%王效增
리소생%산첩%조흔%사아나%왕효증
腺苷%血流储备分数%冠状动脉粥样硬化性心脏病%冠状动脉造影
腺苷%血流儲備分數%冠狀動脈粥樣硬化性心髒病%冠狀動脈造影
선감%혈류저비분수%관상동맥죽양경화성심장병%관상동맥조영
Adenosine%Fractional flow reserve%Coronary disease%Coronary angiography
目的:探讨对中国冠心病人群测定冠状动脉血流储备分数(fractional flow reserve, FFR)中冠状动脉内弹丸式注射腺苷(adenosine, AD)的合适剂量。方法以32例冠心病患者的40支中度狭窄病变冠状动脉血管为研究对象,将60μg(A1)、80μg(A2)、100μg(A3)和120μg(A4)的AD随机以弹丸式注入靶血管进行FFR测定。记录FFR值、注射后不良反应、血流动力学改变及是否存在房室传导阻滞。结果注射后FFR值由基础的0.891±0.044明显下降了8.99%(A1)、11.24%(A2)、13.48%(A3)和13.48%(A4)(均P<0.001)。A3和A4则比A1(t=6.331、6.343,均P<0.001)、A2(t=2.974、3.058,P=0.005、0.004)更低。各剂量组分别有12支(30.0%)、13支(32.5%)、14支(35.0%)和14支(35.0%)靶病变的FFR<0.75。13例(40.6%)患者出现了AD相关不良反应。结论在我国冠心病人群冠状动脉内弹丸式注射AD与FFR测定值具有明显的剂量依赖性,合适的剂量是100μg。
目的:探討對中國冠心病人群測定冠狀動脈血流儲備分數(fractional flow reserve, FFR)中冠狀動脈內彈汍式註射腺苷(adenosine, AD)的閤適劑量。方法以32例冠心病患者的40支中度狹窄病變冠狀動脈血管為研究對象,將60μg(A1)、80μg(A2)、100μg(A3)和120μg(A4)的AD隨機以彈汍式註入靶血管進行FFR測定。記錄FFR值、註射後不良反應、血流動力學改變及是否存在房室傳導阻滯。結果註射後FFR值由基礎的0.891±0.044明顯下降瞭8.99%(A1)、11.24%(A2)、13.48%(A3)和13.48%(A4)(均P<0.001)。A3和A4則比A1(t=6.331、6.343,均P<0.001)、A2(t=2.974、3.058,P=0.005、0.004)更低。各劑量組分彆有12支(30.0%)、13支(32.5%)、14支(35.0%)和14支(35.0%)靶病變的FFR<0.75。13例(40.6%)患者齣現瞭AD相關不良反應。結論在我國冠心病人群冠狀動脈內彈汍式註射AD與FFR測定值具有明顯的劑量依賴性,閤適的劑量是100μg。
목적:탐토대중국관심병인군측정관상동맥혈류저비분수(fractional flow reserve, FFR)중관상동맥내탄환식주사선감(adenosine, AD)적합괄제량。방법이32례관심병환자적40지중도협착병변관상동맥혈관위연구대상,장60μg(A1)、80μg(A2)、100μg(A3)화120μg(A4)적AD수궤이탄환식주입파혈관진행FFR측정。기록FFR치、주사후불량반응、혈류동역학개변급시부존재방실전도조체。결과주사후FFR치유기출적0.891±0.044명현하강료8.99%(A1)、11.24%(A2)、13.48%(A3)화13.48%(A4)(균P<0.001)。A3화A4칙비A1(t=6.331、6.343,균P<0.001)、A2(t=2.974、3.058,P=0.005、0.004)경저。각제량조분별유12지(30.0%)、13지(32.5%)、14지(35.0%)화14지(35.0%)파병변적FFR<0.75。13례(40.6%)환자출현료AD상관불량반응。결론재아국관심병인군관상동맥내탄환식주사AD여FFR측정치구유명현적제량의뢰성,합괄적제량시100μg。
Objective To study the suitable dose of intracoronary adenosine (AD) on fractional flow reserve (FFR) measurement in Chinese patients with angiographic coronary artery disease. Methods FFR was measured in 32 patients with 40 moderate coronary stenosis. Boluses of intracoronary AD at increasing doses of 60μg (A1), 80μg (A2), 100μg (A3) and 120μg (A4) were randomly administered. FFR values, symptoms, systemic effects and development of atrioventricular block were recorded. Results FFR value decreased significantly by 8.99%(A1), 11.24%(A2), 13.48%(A3) and 13.48%(A4) compared with the baseline distal coronary pressure/aortic pressure (0.891±0.044, all P<0.001). A3 and A4 showed significantly lower FFR values than A1 (t=6.331、6.343, all P < 0.001),A2 (t=2.974、3.058, P=0.005、0.004). Positive rates of an FFR of<0.75 were 30.0%(n=12), 32.5%(n=13), 35.0%(n=14) and 35.0%(n=14) in A1, A2, A3 and A4. A total of 13 patients(40.6%) reported at least one side effects. Conclusions This study suggests a dose-response relationship for intracoronary AD on the measurement of FFR in Chinese patients with angiographic coronary artery disease. The suitable dose of bolus of intracoronary AD is 100μg.