CAJ | 학술논문

近年来，活性维生素D独立于调节钙磷代谢外的抗炎、调节细胞凋亡、介导免疫及减少蛋白尿的肾保护作用，成为国内外研究的热点药物。以临床及动物为基础的多数实验数据均有力证明足细胞是其主要的作用靶点，文中就目前的国内外文献关于活性维生素D及其类似物对足细胞保护的作用机制作一综述，展望活性维生素D在未来的应用前景。
근년래，활성유생소D독립우조절개린대사외적항염、조절세포조망、개도면역급감소단백뇨적신보호작용，성위국내외연구적열점약물。이림상급동물위기출적다수실험수거균유력증명족세포시기주요적작용파점，문중취목전적국내외문헌관우활성유생소D급기유사물대족세포보호적작용궤제작일종술，전망활성유생소D재미래적응용전경。
In recent years , active vitamin D is a hot research drugs because of its renal protective effect of independent regu -lation of anti-inflammatory effects outside calcium and phosphorus metabolism , regulation of apoptosis , mediated immunity and reduc-tion of proteinuria .Podocyte is the main target of active vitamin D based on the result of clinical and animal studies .In this article, we review the current literature on mechanism of active vitamin D and its analogues on the protection of podocytes about and give the clini -cal perspectives of activity vitamin D .