医学研究生学报
醫學研究生學報
의학연구생학보
JOURNAL OF MEDICAL POSTGRADUATE
2014年
8期
874-877
,共4页
段家翔(综述)%甯交琳%鲁开智(审校)
段傢翔(綜述)%甯交琳%魯開智(審校)
단가상(종술)%녕교림%로개지(심교)
核因子E2相关因子2%出核转运%氧化应激
覈因子E2相關因子2%齣覈轉運%氧化應激
핵인자E2상관인자2%출핵전운%양화응격
Nrf2%Nuclear export%Oxidant stress
核因子E2相关因子2(nuclear factor -E2-related factor 2, Nrf2)是C′n′C转录因子家族成员之一,在各种组织细胞中广泛表达,是细胞调节抗氧化应激反应的重要转录因子。近年来研究发现Nrf2完成抗氧化应激基因诱导后快速降解与其转录激活同样重要,而Nrf2的出核转运是在细胞质中快速降解的前提。文中就目前Nrf2出核转运机制的研究进展作一综述。
覈因子E2相關因子2(nuclear factor -E2-related factor 2, Nrf2)是C′n′C轉錄因子傢族成員之一,在各種組織細胞中廣汎錶達,是細胞調節抗氧化應激反應的重要轉錄因子。近年來研究髮現Nrf2完成抗氧化應激基因誘導後快速降解與其轉錄激活同樣重要,而Nrf2的齣覈轉運是在細胞質中快速降解的前提。文中就目前Nrf2齣覈轉運機製的研究進展作一綜述。
핵인자E2상관인자2(nuclear factor -E2-related factor 2, Nrf2)시C′n′C전록인자가족성원지일,재각충조직세포중엄범표체,시세포조절항양화응격반응적중요전록인자。근년래연구발현Nrf2완성항양화응격기인유도후쾌속강해여기전록격활동양중요,이Nrf2적출핵전운시재세포질중쾌속강해적전제。문중취목전Nrf2출핵전운궤제적연구진전작일종술。
Nuclear factor-E2-related factor 2(Nrf2)is a member of C′n′C transcription factor family.It is an important transcrip-tion factor for regulation of cellular redox status and can be seen in all kinds of tissues .Recent studies have demonstrated that rapid deg-radation of Nrf2 after gene-induced antioxidative stress is as important as transcription and activation of Nrf 2 and the nuclear export of Nrf2 is a prerequisite for rapid degradation of Nrf2 in the cytosol.This review focuses on the mechanism of nuclear export of Nrf 2.