CAJ | 학술논문

Notch-1是Notch基因家族的成员之一，Notch-1信号通路在细胞的增殖、分化、生存和凋亡中起着重要作用，其异常表达与肿瘤的发生、发展密切相关。近年来， Notch-1信号通路和肿瘤的关系研究颇多。文中就该信号通路在肿瘤中的研究进展作一综述。
Notch-1시Notch기인가족적성원지일，Notch-1신호통로재세포적증식、분화、생존화조망중기착중요작용，기이상표체여종류적발생、발전밀절상관。근년래， Notch-1신호통로화종류적관계연구파다。문중취해신호통로재종류중적연구진전작일종술。
As one of members of the Notch gene family , Notch-1 signaling pathway plays an important role in the processing of cell proliferation , differentiation , survival and apoptosis .The abnormal expression of Notch-1 is closely related to tumorigenesis and de-velopment .In recent years , many studies have focused on the relationship between the Notch-1 signaling pathway and tumor .This arti-cle reviews the achievement of Notch-1 signaling pathway in recent tumor researches .