CAJ | 학술논문

目的：探讨富于T细胞/组织细胞型的弥漫大B细胞性淋巴瘤(TCRBCL)的病理形态、预后和免疫组化的特点及鉴别诊断。方法：根据WHO淋巴瘤分类(2008版)的标准对4例TCRBCL进行临床、组织病理和免疫组化分析，应用全自动免疫组化仪(DAKO)检测瘤细胞及背景细胞的免疫表型，抗体包括CD20，CD79a， CD3，CD15，CD68，CD30、CD10，BCL-6，CD21。结果：少量肿瘤性大细胞分布于小淋巴细胞及组织细胞背景中，免疫组化肿瘤性大细胞CD20阳性，背景小细胞CD3阳性，组织细胞CD68阳性。结论：TCRBCL是一个独立的组织学类型，是弥漫大B细胞性淋巴瘤的形态学变异体，易误诊为霍奇金淋巴瘤、反应性淋巴组织增生、淋巴瘤样肉芽肿病等，诊断应结合形态学和免疫表型特征。
목적：탐토부우T세포/조직세포형적미만대B세포성림파류(TCRBCL)적병리형태、예후화면역조화적특점급감별진단。방법：근거WHO림파류분류(2008판)적표준대4례TCRBCL진행림상、조직병리화면역조화분석，응용전자동면역조화의(DAKO)검측류세포급배경세포적면역표형，항체포괄CD20，CD79a， CD3，CD15，CD68，CD30、CD10，BCL-6，CD21。결과：소량종류성대세포분포우소림파세포급조직세포배경중，면역조화종류성대세포CD20양성，배경소세포CD3양성，조직세포CD68양성。결론：TCRBCL시일개독립적조직학류형，시미만대B세포성림파류적형태학변이체，역오진위곽기금림파류、반응성림파조직증생、림파류양육아종병등，진단응결합형태학화면역표형특정。
Objective:To explore pathological morphology, the prognosis, immunohistochemical features and differential diagnosis of T cell/histocyte-rich B cell lymphoma (TCRBCL). Methods:Four cases of TCRBCL were analyzed from clinical, histopathological and immunohis chemical aspects according to the standard of WHO lym-phoma classification (2008 edition), the immunophenotypes of tumor cells and background cells were detected by automatic immunohistochemical instruments (DAKO), antibodies contained CD20, CD79a, CD3, CD15, CD68, CD30, CD10, BCL-6 and CD21. Results:There were a small amount of tumorous magacells distributed in the tis- <br> sues of small lymphocytes and histocytes, immunohistochemical tumorous magacells CD20 positive, background cellule CD3 positive, histocytes CD68 positive. Conclusion:TCRBCL is an independent histological type and mor-phological variant of B cell lymphoma, it might be misdiagnosed as hodykin lymphoma, reactive lymphadenia, lym-phomatoid granulomatosis and others, the diagnosis shoule be based on the morphology and the features of im-munophenotype.