CAJ | 학술논문

目的：探讨糖网康对视网膜功能的保护作用。方法：将40只自发性糖尿病GK大鼠随机分为4组：模型对照组、糖网康低、中、高剂量组，各组分别灌胃2 mL蒸馏水、150 mg/kg糖网康、300 mg/kg糖网康、600 mg/kg糖网康。每日灌胃1次，连续给药1个月，记录大鼠明视闪光视网膜电图（fERG）a波、b波和Ops波，并将数据统计分析。结果：用药后中药中高剂量组比其他各组用药后的a波、Ops波振幅提高，差异有显著的统计学意义，a波波峰潜时比较差异有统计学意义，潜时缩短；中药中低剂量组比其他各组的b波振幅提高，差异有统计学意义（P＜0.05），b波峰潜时比较差异有统计学意义，潜时缩短。中药糖网康能提高糖尿病大鼠fERG的振幅，缩短潜时，尤其是对Ops干预作用明显。结论：中药糖网康对糖尿病模型的早期视网膜功能损害，尤其是视网膜内层血液循环状态的改善具有一定作用。
목적：탐토당망강대시망막공능적보호작용。방법：장40지자발성당뇨병GK대서수궤분위4조：모형대조조、당망강저、중、고제량조，각조분별관위2 mL증류수、150 mg/kg당망강、300 mg/kg당망강、600 mg/kg당망강。매일관위1차，련속급약1개월，기록대서명시섬광시망막전도（fERG）a파、b파화Ops파，병장수거통계분석。결과：용약후중약중고제량조비기타각조용약후적a파、Ops파진폭제고，차이유현저적통계학의의，a파파봉잠시비교차이유통계학의의，잠시축단；중약중저제량조비기타각조적b파진폭제고，차이유통계학의의（P＜0.05），b파봉잠시비교차이유통계학의의，잠시축단。중약당망강능제고당뇨병대서fERG적진폭，축단잠시，우기시대Ops간예작용명현。결론：중약당망강대당뇨병모형적조기시망막공능손해，우기시시망막내층혈액순배상태적개선구유일정작용。
Objective:To discuss the function of TangWangKang on retinal function. Methods:Forty GK rats with spontaneous diabetes mellitus (DM) were randomized into four groups:model control group, low dosage group, moderate dosage group and high dosage group, all the groups above were perfused with distilled water, 2 mL, 150 mg/kg TangWangKang, 300 mg/kg TangWangKang, and 600 mg/kg TangWangKang, once per day, administered with the drugs for one month consecutively, a wave, b wave and Ops wave of flash electroretinogram (fERG) of the rats were recorded and analyzed statistically. Results: After the medication, herb groups of moderate and high dosage were higher than other groups in heightening the amplitudes of a wave and Ops wave, the difference showed notable statistical meaning, the difference showed statistical meaning in the peak latency of a wave, the latency was short-ened;after the medication, herb group of moderate dosage was raised compared with other groups in increasing the amplitude of b wave, the difference showed statistical meaning (P<0.05), the difference showed statistical meaning in the peak latency of b wave, the latency was cut down. TangWangKang could significantly increase the amplitude of fERG of DM rats, cut down the latency, especially intervene Ops obviously. Conclusion: TangWangKang could improve early injury of retinal function in DM rat models, especially intimal blood circulation of retina in a certain degree.