CAJ | 학술논문

目的：评估含红芪和含黄芪益气养血汤对衰老小鼠体内抗氧化损伤及抗免疫衰老作用的效果及差异。方法：用相同剂量红芪替换益气养血汤中的黄芪，灌胃18个月龄老龄鼠。测定老龄小鼠脾脏、胸腺指数，检测老龄小鼠血清超氧化物歧化酶(SOD)活力、丙二醛(MDA)水平和血清IL-2含量。结果：含红芪和含黄芪的益气养血汤均可提高老龄小鼠脾脏和胸腺指数，在提高脾脏指数方面红芪作用优于黄芪。2种药物均可提高血清SOD活力，降低MDA水平，且二者作用无差异（P＞0.05）。含红芪和含黄芪的益气养血汤均可升高老龄小鼠血清IL-2含量且红芪作用优于黄芪（P＜0.05）。结论：含红芪和含黄芪的益气养血汤对老龄小鼠有一定的抗氧化损伤和抗免疫衰老效果，且红芪作用与黄芪作用相当。含红芪的益气养血汤在提高老龄小鼠脾脏指数，提高血清IL-2含量方面优于含黄芪益气养血汤。
목적：평고함홍기화함황기익기양혈탕대쇠로소서체내항양화손상급항면역쇠로작용적효과급차이。방법：용상동제량홍기체환익기양혈탕중적황기，관위18개월령노령서。측정노령소서비장、흉선지수，검측노령소서혈청초양화물기화매(SOD)활력、병이철(MDA)수평화혈청IL-2함량。결과：함홍기화함황기적익기양혈탕균가제고노령소서비장화흉선지수，재제고비장지수방면홍기작용우우황기。2충약물균가제고혈청SOD활력，강저MDA수평，차이자작용무차이（P＞0.05）。함홍기화함황기적익기양혈탕균가승고노령소서혈청IL-2함량차홍기작용우우황기（P＜0.05）。결론：함홍기화함황기적익기양혈탕대노령소서유일정적항양화손상화항면역쇠로효과，차홍기작용여황기작용상당。함홍기적익기양혈탕재제고노령소서비장지수，제고혈청IL-2함량방면우우함황기익기양혈탕。
Objective: To evaluate the effects and the differences between YiQi YangXue Tang containing HongQi (Hedysarum polybotrys Hand.-Mazz.) and the one containing HuangQi [Astragalus membranaceus (Fisch.) <br> Bunge.] on anti-oxidative damage and anti-aging of senile rats. Methods:The same doses of HongQi were used to re-place HuangQi in the prescription of YiQi Y angXue Tang, the decoction was given to senile rats at the age of 18 months by lavage. Spleen and thymus indexes of senile rats were detected, the contents of serum IL-2, the level of MDA and the activity of SOD were also measured. Results: YiQi YangXue Tang containing HongQi or HuangQi could raise spleen and thymus indexes of senile rats, HongQi was superior to HuangQi in improving spleen index. Both drugs could improve the activity of SOD and decrease the level of MDA, and there was no difference between them (P>0.05). The decoction containing HongQi or HuangQi could improve the contents of IL-2, HongQi was su-perior to HuangQi (P<0.05). Conclusion:YiQi YangXue Tang containing HongQi or HuangQi shows the effects of anti-oxidative damage and anti-aging to senile rats in a certain degree, and HongQi is equivalent to HuangQi. The de-coction containing HongQi is superior to the one containing HuangQi in improving spleen index and the content of IL-2 in the serum.